Siebenmann R E
Schweiz Med Wochenschr. 1977 Apr 9;107(14):468-74.
Stiffening and tenderness of the helix of the ear, with radiologically demonstrable calcific deposits, has been reported in various conditions such as frostbite, and also in Addison's disease. To a total of 14 clinical observations with only 4 well documented cases, a first autopsy report of the disorder in a case of tuberculosus Addison's disease is added. It is shown that the elastic cartilage of the pinna, of the epiglottis and of the trachea undergoes ossification without preceding dystrophic or metastatic calcification. The ossification has been observed only in males with longstanding Addison's disease treated exclusively with mineralocorticoids over a long period. The possible pathogenetic mechanisms are discussed. An important factor seems to be the long-standing glucocorticoid deficiency.
耳轮的僵硬和压痛，伴有放射学上可证实的钙化沉积，已在多种病症中被报道，如冻伤，也见于艾迪生病。在总共14例临床观察中，仅有4例记录完善的病例，现补充一例结核性艾迪生病患者该病症的首例尸检报告。结果显示，耳廓、会厌和气管的弹性软骨发生骨化，且无先前的营养不良性或转移性钙化。骨化仅在长期患有艾迪生病且长期仅接受盐皮质激素治疗的男性中观察到。文中讨论了可能的发病机制。一个重要因素似乎是长期的糖皮质激素缺乏。
