LECT2-PHB2 axis: a new mechanistic insight and therapeutic opportunity in alcohol-associated hepatitis.
作者信息
Li Hui, Song Meiyi, Hylemon Phillip B, Zhou Huiping
机构信息
Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
出版信息
Gut. 2025 May 13. doi: 10.1136/gutjnl-2025-335259.
Abstract
摘要
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本文引用的文献
1
Stressed hepatocyte sustains alcohol-associated hepatitis progression by producing leukocyte cell-derived chemotaxin 2.应激的肝细胞通过产生白细胞衍生趋化因子2促进酒精性肝炎进展。
Gut. 2025 Jul 7;74(8):1321-1334. doi: 10.1136/gutjnl-2024-334318.
2
Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis.中性粒细胞将弹性蛋白酶插入肝细胞中，以调节酒精性肝炎中的钙信号转导。
J Clin Invest. 2024 Jun 25;134(16):e171691. doi: 10.1172/JCI171691.
3
Inflammation in Alcohol-Associated Hepatitis: Pathogenesis and Therapeutic Targets.酒精性肝炎中的炎症：发病机制和治疗靶点。
Cell Mol Gastroenterol Hepatol. 2024;18(3):101352. doi: 10.1016/j.jcmgh.2024.04.009. Epub 2024 May 1.
4
IL-8+ neutrophils drive inexorable inflammation in severe alcohol-associated hepatitis.白细胞介素-8阳性中性粒细胞在严重酒精性肝炎中引发不可阻挡的炎症。
J Clin Invest. 2024 Mar 19;134(9):e178616. doi: 10.1172/JCI178616.
5
The emerging roles of leukocyte cell-derived chemotaxin-2 in immune diseases: From mechanisms to therapeutic potential.白细胞细胞衍生趋化因子-2 在免疫疾病中的新兴作用：从机制到治疗潜力。
Front Immunol. 2023 Mar 9;14:1158083. doi: 10.3389/fimmu.2023.1158083. eCollection 2023.
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Gastroenterology. 2023 Jun;164(7):1248-1260. doi: 10.1053/j.gastro.2023.02.023. Epub 2023 Feb 26.
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Neutrophil extracellular traps contribute to liver damage and increase defective low-density neutrophils in alcohol-associated hepatitis.中性粒细胞胞外诱捕网促进酒精性肝炎肝损伤并增加缺陷性低密度中性粒细胞。
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Hepatology. 2023 Jan 1;77(1):159-175. doi: 10.1002/hep.32604. Epub 2022 Jul 5.
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