Kwak Dong Wook, Kim Seokyung, Lee Su Young, Park Hee Jin, Han You Jung, Kim Moon Young, Chung Jin Hoon, Lim Ji Hyae, Ryu Hyun Mee
Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea (the Republic of).
Department of Psychiatry, Yonsei Forest Mental Health Clinic, Seoul, Korea (the Republic of).
BMJ Ment Health. 2025 May 13;28(1):e301465. doi: 10.1136/bmjment-2024-301465.
Anaemia during pregnancy is associated with maternal depressive symptoms during pregnancy and the postpartum period. However, the effect of anaemia development during pregnancy on maternal psychological health in non-anaemic women remains unclear.
To investigate the effect of anaemia development during pregnancy on maternal psychological health during pregnancy and the postpartum period.
This study includes a secondary analysis of data collected prospectively from the Korean Pregnancy Outcome Study. Depression and anxiety were evaluated in each trimester and 4-6 weeks postpartum. The Hospital Anxiety and Depression Scale was used for anxiety and the Edinburgh Postnatal Depression Scale for depression.
Among 3310 women with normal haemoglobin concentrations in the first trimester, 270 (8.1%) developed anaemia in the third trimester. Depression during the first trimester and anxiety during the second trimester were significantly more frequent among patients who later developed anaemia in the third trimester than among those who did not. Even after adjusting for confounding factors, anaemia development during pregnancy was significantly associated with increased risks of depression during the first trimester (aOR, 1.45; 95% CI, 1.07 to 1.96; p=0.017) and anxiety during the second trimester (aOR, 1.57; 95% CI, 1.04 to 2.38; p=0.033), respectively.
Among women who were non-anaemic in the first trimester and developed anaemia by the third trimester, higher risks of maternal depression and anxiety were observed during the first and second trimester, respectively. It suggests that a decrease in haemoglobin concentrations during pregnancy negatively impacts on maternal psychological health.
孕期贫血与孕期及产后母亲的抑郁症状有关。然而，孕期贫血的发生对非贫血女性母亲心理健康的影响尚不清楚。
探讨孕期贫血的发生对孕期及产后母亲心理健康的影响。
本研究包括对韩国妊娠结局研究前瞻性收集的数据进行二次分析。在妊娠各期及产后4 - 6周评估抑郁和焦虑情况。采用医院焦虑抑郁量表评估焦虑，爱丁堡产后抑郁量表评估抑郁。
在孕早期血红蛋白浓度正常的3310名女性中，270名（8.1%）在孕晚期发生贫血。孕晚期发生贫血的患者中，孕早期的抑郁和孕中期的焦虑明显比未发生贫血的患者更常见。即使在调整混杂因素后，孕期贫血的发生仍分别与孕早期抑郁风险增加（调整后比值比，1.45；95%置信区间，1.07至1.96；p = 0.017）和孕中期焦虑风险增加（调整后比值比，1.57；95%置信区间，1.04至2.38；p = 0.033）显著相关。
在孕早期非贫血且到孕晚期发生贫血的女性中，分别在孕早期和孕中期观察到母亲抑郁和焦虑的风险更高。这表明孕期血红蛋白浓度降低对母亲心理健康有负面影响。
