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Structural insights into ligand recognition and activation of human purinergic receptor P2Y14.

作者信息

Gu Quanchang, Lv Zhenyu, Wang Tianxin, Tang Wenqin, Guo Xuzhen, Huang Xiangling, Li Fahui, Wang Jiangyun

机构信息

CAS Key Laboratory of Quantitative Engineering Biology, Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.

Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

出版信息

Cell Discov. 2025 May 13;11(1):48. doi: 10.1038/s41421-025-00799-9.

DOI:10.1038/s41421-025-00799-9
PMID:40360473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12075594/
Abstract
摘要

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Structural insights into ligand recognition and activation of human purinergic receptor P2Y14.人类嘌呤能受体P2Y14配体识别与激活的结构洞察
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2
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The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver.嘌呤能P2Y14受体将肝细胞死亡与肝星状细胞激活及肝脏纤维化联系起来。
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Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor.对Gi介导的腺苷酸环化酶活性抑制作用的定量分析表明，UDP是人类P2Y14受体的有效激动剂。
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本文引用的文献

1
Discovery of a Series of 4-Amide-thiophene-2-carboxyl Derivatives as Highly Potent P2Y Receptor Antagonists for Inflammatory Bowel Disease Treatment.发现一系列 4-酰胺噻吩-2-羧酸衍生物作为治疗炎症性肠病的高效 P2Y 受体拮抗剂。
J Med Chem. 2024 Jul 25;67(14):11989-12011. doi: 10.1021/acs.jmedchem.4c00699. Epub 2024 Jul 3.
2
Identification of a carbohydrate recognition motif of purinergic receptors.鉴定嘌呤能受体的碳水化合物识别基序。
Elife. 2023 Nov 13;12:e85449. doi: 10.7554/eLife.85449.
3
Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding.
通过配体结合解析羟酸受体信号转导机制的结构基础。
Nat Commun. 2023 Sep 22;14(1):5899. doi: 10.1038/s41467-023-41650-7.
4
Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R.嘌呤能受体P2Y1R和P2Y12R信号转导的结构见解。
Protein Cell. 2023 May 8;14(5):382-386. doi: 10.1093/procel/pwac025.
5
The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver.嘌呤能P2Y14受体将肝细胞死亡与肝星状细胞激活及肝脏纤维化联系起来。
Sci Transl Med. 2022 Apr 6;14(639):eabe5795. doi: 10.1126/scitranslmed.abe5795.
6
Adipocyte P2Y14 receptors play a key role in regulating whole-body glucose and lipid homeostasis.脂肪细胞 P2Y14 受体在调节全身葡萄糖和脂质稳态方面发挥着关键作用。
JCI Insight. 2021 May 24;6(10):146577. doi: 10.1172/jci.insight.146577.
7
Uridine diphosphate-glucose/P2Y14R axis is a nonchemokine pathway that selectively promotes eosinophil accumulation.尿苷二磷酸葡萄糖/ P2Y14R 轴是一种非趋化因子途径，可选择性促进嗜酸性粒细胞积聚。
J Clin Invest. 2021 Apr 1;131(7). doi: 10.1172/JCI147735.
8
Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice.促炎型 P2Y14 受体抑制可预防小鼠缺血性急性肾损伤。
J Clin Invest. 2020 Jul 1;130(7):3734-3749. doi: 10.1172/JCI134791.
9
Glycogen metabolism regulates macrophage-mediated acute inflammatory responses.糖原代谢调节巨噬细胞介导的急性炎症反应。
Nat Commun. 2020 Apr 14;11(1):1769. doi: 10.1038/s41467-020-15636-8.
10
Adenine nucleotides as paracrine mediators and intracellular second messengers in immunity and inflammation.腺嘌呤核苷酸作为免疫和炎症中的旁分泌介质和细胞内第二信使。
Biochem Soc Trans. 2019 Feb 28;47(1):329-337. doi: 10.1042/BST20180419. Epub 2019 Jan 23.