Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Department of Immunology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Biochem Soc Trans. 2019 Feb 28;47(1):329-337. doi: 10.1042/BST20180419. Epub 2019 Jan 23.
Adenine nucleotides (AdNs) play important roles in immunity and inflammation. Extracellular AdNs, such as adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD) and their metabolites, act as paracrine messengers by fine-tuning both pro- and anti-inflammatory processes. Moreover, intracellular AdNs derived from ATP or NAD play important roles in many cells of the immune system, including T lymphocytes, macrophages, neutrophils and others. These intracellular AdNs are signaling molecules that transduce incoming signals into meaningful cellular responses, e.g. activation of immune responses against pathogens.
腺嘌呤核苷酸 (AdNs) 在免疫和炎症中发挥重要作用。细胞外 AdNs，如三磷酸腺苷 (ATP) 或烟酰胺腺嘌呤二核苷酸 (NAD) 及其代谢物，通过精细调节促炎和抗炎过程，充当旁分泌信使。此外，来自 ATP 或 NAD 的细胞内 AdNs 在免疫系统的许多细胞中发挥重要作用，包括 T 淋巴细胞、巨噬细胞、中性粒细胞等。这些细胞内 AdNs 是信号分子，将传入信号转导为有意义的细胞反应，例如激活针对病原体的免疫反应。
