Lazarov G, Tsanev A
Vutr Boles. 1985;24(2):97-101.
A case is described with multiple gangrene of the fingers of a female, aged 55, with confirmed cirrhosis of liver and diabetes mellitus. Cryoglobulins were established in the serum. A disturbed immunological balance was present and the family loading with collagenosis raises the problem of genetic moments of the disturbed homeostasis. The existing diabetic microangiopathy, histologically confirmed by biopsy of skin and subcutaneous tissue, brings forward the question of the complex pathogenesis of gangrene. At the end of her stay in the clinic, the patient developed cerebral apoplexy.
本文描述了一名55岁女性患者，手指多处坏疽，确诊为肝硬化和糖尿病。血清中检测到冷球蛋白。存在免疫平衡紊乱，且家族中有胶原病患者，这引发了内环境稳态紊乱的遗传因素问题。经皮肤和皮下组织活检组织学证实存在糖尿病微血管病变，这也提出了坏疽复杂发病机制的问题。患者在诊所住院期间末期发生了脑中风。
