Vacula I, Ambrózy E, Makovník M, Stvrtina S, Babál P, Stvrtinová V
2nd Department of Internal Medicine, Comenius University Hospital, Bratislava, Slovakia.
Int Angiol. 2010 Dec;29(6):560-4.
Cryoglobulinemia is a rather rare condition accompanying quite a broad spectrum of different states and diseases. Mixed or polyclonal cryoglobulins can be seen in patients with autoimmune disorders, chronic infections and lymphoproliferative disorders. Monoclonal cryoglobulins are often revealed in patients with multiple myeloma or Waldenström's macroglobulinemia. Cryoglobulinemia is in most cases asymptomatic. Cryoglobulinemic vasculitis is an immune complex-mediated systemic disorder involving mostly small, but sometimes also larger vessels. In this report, we describe a case of a patient presented with gangrene of almost all fingers and toes, who was finally diagnosed and treated as cryoglobulinemic vasculitis due to multiple myeloma.
冷球蛋白血症是一种相当罕见的病症，伴随多种不同的状态和疾病。混合性或多克隆冷球蛋白可见于自身免疫性疾病、慢性感染和淋巴增殖性疾病患者。单克隆冷球蛋白常出现在多发性骨髓瘤或华氏巨球蛋白血症患者中。大多数情况下，冷球蛋白血症是无症状的。冷球蛋白血症性血管炎是一种免疫复合物介导的全身性疾病，主要累及小血管，但有时也会累及较大血管。在本报告中，我们描述了一例几乎所有手指和脚趾均出现坏疽的患者，该患者最终被诊断为多发性骨髓瘤所致的冷球蛋白血症性血管炎并接受了治疗。
