Ping Luyi, Huang Yulin, Sun Gufeng, Jin Lin, Huang Xu, Zhang Chunquan, Wang Jiwei
Department of Ultrasound, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No.1,Minde Road, Dong hu District, Jiangxi Province, 330000, Nanchang, China.
Emergency Department, Jiangxi Provincial Children's Hospital, Nanchang, 330000, Jiangxi Province, China.
BMC Cardiovasc Disord. 2025 May 13;25(1):363. doi: 10.1186/s12872-025-04825-2.
This study aimed to detect early left atrial (LA) function abnormalities in young hypertensive patients with a normal two-dimensional LA volume index (2D-LAVI) using four-dimensional auto LA quantification technology (4D Auto LAQ) and to analyse correlations between LA strain parameters and clinical metabolic indicators.
This study enrolled 70 young patients who underwent standard hypertension treatment or diagnosis at the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, from October 2023 to July 2024 and 41 control volunteers enrolled during the same period. LA volume and strain parameters were evaluated with a 4D Auto LAQ. A correlation analysis was conducted between the clinical and strain parameters.
Compared with the control group, young hypertensive patients presented significantly greater LA minimum volume (LAVmin), LA minimum volume index (LAVImin) and LA pre-atrial volume (LAVpreA) values (all p < 0.001). The LA ejection fraction (LAEF) was reduced in young hypertensive patients (57.85%±4.47% vs. 50.44%±5.96%, p < 0.001), along with LA reservoir longitudinal strain (25.00% [20.50-29.50%] vs. 20.00% [16.00-24.25%], p < 0.001), LA conduit longitudinal strain (-16.32%±4.19% vs. -11.37%±4.65%, p < 0.001), LA contraction longitudinal strain (-12.27%±2.85% vs. -9.60 ± 4.12, p < 0.001), LA reservoir circumferential strain (34.32%±6.90% vs. 28.41%±6.95%, p < 0.001), LA conduit circumferential strain (-17.90%±4.84% vs. -11.46%±4.96%, p < 0.001), and LA contraction circumferential strain (-18.54%±4.85% vs. -16.23%±6.11%, p < 0.05). Multivariate linear regression analysis revealed that body mass index (BMI), triglyceride (TG), and uric acid (UA) were negatively and independently correlated with LA longitudinal strain.
In young hypertensive patients with normal 2D-LAVI, while LAVmin, LAVImin and LAVpreA are elevated, the LAEF and LA reservoir, conduit, and contraction strain are notably reduced. The application of 4D Auto LAQ technology may highlight altered values in young hypertensive patients with normal 2D-LAVI. 4D Auto LAQ may serve as a valuable tool for clinicians in the early detection and assessment of LA dysfunction in young hypertensive patients.
本研究旨在使用四维自动左心房定量技术（4D自动LAQ）检测二维左心房容积指数（2D-LAVI）正常的年轻高血压患者早期左心房（LA）功能异常，并分析LA应变参数与临床代谢指标之间的相关性。
本研究纳入了2023年10月至2024年7月在南昌大学江西医学院第二附属医院接受标准高血压治疗或诊断的70名年轻患者，以及同期招募的41名对照志愿者。使用4D自动LAQ评估LA容积和应变参数。对临床参数和应变参数进行相关性分析。
与对照组相比，年轻高血压患者的LA最小容积（LAVmin）、LA最小容积指数（LAVImin）和LA心房前容积（LAVpreA）值显著更高（均p<0.001）。年轻高血压患者的LA射血分数（LAEF）降低（57.85%±4.47%对50.44%±5.96%，p<0.001），同时LA储存器纵向应变（25.00%[20.50-29.50%]对20.00%[16.00-24.25%]，p<0.001）、LA管道纵向应变（-16.32%±4.19%对-11.37%±4.65%，p<0.001）、LA收缩纵向应变（-12.27%±2.85%对-9.60±4.12，p<0.001）、LA储存器圆周应变（34.32%±6.90%对28.4
