Gade Shubhda, Sahasrabuddhe Anagha V, Mohite Kajal A, Bankar Nandkishor J, Chaudhary Shilpa S, Muley Parikshit A, Muley Pranjali P
Physiology, Datta Meghe Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.
Microbiology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.
Cureus. 2023 Apr 6;15(4):e37232. doi: 10.7759/cureus.37232. eCollection 2023 Apr.
Left ventricular systolic and diastolic functions are known prognosticators for cardiovascular morbidity. One of the significant risk factors for cardiovascular diseases is obesity. The objective of this study is to determine the effect of obesity on the systolic and diastolic functions of the left ventricle on the basis of echocardiographic indices.
75 obese and 75 averagely built subjects were studied. They had no other comorbidities. The indices of echocardiography of systolic and diastolic function were taken and assessed using recent recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography.
The volume indices of systolic and diastolic function (ejection diastolic volume (EDV) and ejection systolic volume (ESV)) and iso-volumetric relaxation time (IVRT) showed a significant increase in obese subjects (p<0.05); however, the relative thickness of the wall and internal diameter were comparable to non-obese subjects. The indices of contractility like ejection fraction, early diastolic filling velocity and late diastolic filling velocity (E/A) ratio, and mitral annular velocity were significantly lower in the obese subjects as compared to non-obese subjects. It was also found that left atrial diameter in systole and diastole had a moderate association (r=0.48, P<0.0001; r=0.35, P<0.0005) while mitral inflow E/A ratio had a negative association with body mass index (BMI) (r=-0.26, P=0.0166).
Volumetric changes and ejection are significantly altered by increased BMI. More comprehensive studies in the future are recommended to assess the same.
左心室收缩和舒张功能是已知的心血管疾病发病率的预后指标。肥胖是心血管疾病的重要危险因素之一。本研究的目的是基于超声心动图指标确定肥胖对左心室收缩和舒张功能的影响。
对75名肥胖受试者和75名体型正常的受试者进行了研究。他们没有其他合并症。采用欧洲心血管影像协会和美国超声心动图学会的最新建议，获取并评估收缩和舒张功能的超声心动图指标。
肥胖受试者的收缩和舒张功能容积指标（舒张末期容积（EDV）和收缩末期容积（ESV））以及等容舒张时间（IVRT）显著增加（p<0.05）；然而，室壁相对厚度和内径与非肥胖受试者相当。与非肥胖受试者相比，肥胖受试者的收缩性指标如射血分数、舒张早期充盈速度和舒张晚期充盈速度（E/A）比值以及二尖瓣环速度显著降低。还发现，收缩期和舒张期左心房直径存在中度相关性（r=0.48，P<0.0001；r=0.35，P<0.0005），而二尖瓣流入E/A比值与体重指数（BMI）呈负相关（r=-0.26，P=0.0166）。
BMI升高会显著改变容积变化和射血情况。建议未来进行更全面的研究以评估这一情况。
