T-Dark Rim as a Marker of New and Chronic Active Multiple Sclerosis Lesions: A Serial Study With Frequent 7T MRI.

BACKGROUND AND PURPOSE

Chronic active multiple sclerosis (MS) lesions represent a particularly destructive subset of lesions on pathology. However, their imaging correlates, including paramagnetic rim lesions (PRLs) detected on susceptibility-weighted imaging, lack sensitivity and are difficult to implement in clinical practice. This exploratory, longitudinal study investigates the prevalence and temporal dynamics of a novel imaging marker, T-dark rims, and their relationship with PRLs observed on quantitative susceptibility mapping (QSM).

METHODS

Four untreated people with MS underwent 7-Tesla MRI scanning six times over a period of 36 weeks. New and pre-existing lesions were analyzed for the presence and temporal evolution of T-dark and QSM rims. Quantitative T values were derived using B maps, and the relationship between rim status and lesion size was evaluated.

RESULTS

Of the 159 baseline lesions, 22 (14%) had T-dark rims, 11 (7%) had QSM rims, and five lesions had both. T-dark and QSM rims showed temporal changes, with T-dark rims preceding new QSM rim appearance in three out of four (75%) lesions. Eleven out of 20 (55%) newly formed lesions had T-dark rims, with a T-dark rim present in all new lesions over 100 mm. Small new lesions lacked discernible rims, but their overall T values aligned with those of larger lesion T-dark rims implying shared pathological processes.

CONCLUSIONS

T-dark rims were more common than QSM rims, with greater prevalence in newly formed lesions. We propose they represent edema and inflammation associated with early stages of chronic active lesion formation visible despite, not because of, iron accumulation.