Song Chang Myeon, Kim Yun Jin, Cheong Hyun Sub, Ji Yong Bae, Tae Kyung
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea.
Department of Pre-Medicine, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea.
Cancers (Basel). 2025 Apr 26;17(9):1456. doi: 10.3390/cancers17091456.
: We sought to evaluate the association between the risk of papillary thyroid carcinoma (PTC) and single-nucleotide polymorphisms (SNPs) of breast cancer genes 1 () and 2 (). : We prospectively recruited 515 cases with PTC and 296 controls without cancer. The genotypes of five SNPs (rs8176318, rs1799966, rs799917, rs16940, rs1799949) and three SNPs (rs15869, rs1799943, rs1799955) were determined using the TaqMan assay. We evaluated the association of haplotypes with the risk of PTC due to linkage disequilibrium (LD). : The five SNPs were significantly associated with the risk of PTC. The AC genotype of rs8176318 (OR = 0.69, = 0.02) and the CT and CC genotypes of rs1799966 (OR = 0.70, = 0.02 and OR = 0.67, = 0.01, respectively) were associated with a decreased risk of PTC. The AG genotype of rs16940 (OR = 0.67, = 0.01) and the AG genotypes of rs799917 and rs1799949 (both OR = 0.70, = 0.02) decreased the risk of PTC. Haplotype 1 [rs8176318(C)-rs1799966(T)-rs799917(G)-rs16940(A)-rs1799949(G)] ± (OR = 0.69, = 0.02) and haplotype 2 [rs8176318(A)-rs1799966(C)-rs799917(A)-rs16940(G)-rs1799949(A)] ± (OR = 0.71, = 0.03) of reduced the risk of PTC. : Our findings suggest that the polymorphisms of may contribute to the susceptibility to PTC in the Korean population.
我们试图评估甲状腺乳头状癌（PTC）风险与乳腺癌1基因（ ）和2基因（ ）的单核苷酸多态性（SNP）之间的关联。我们前瞻性招募了515例PTC患者和296例无癌症的对照。使用TaqMan检测法确定了5个 SNP（rs8176318、rs1799966、rs799917、rs16940、rs1799949）和3个 SNP（rs15869、rs1799943、rs1799955）的基因型。由于连锁不平衡（LD），我们评估了单倍型与PTC风险的关联。5个 SNP与PTC风险显著相关。rs8176318的AC基因型（OR = 0.69， = 0.02）以及rs1799966的CT和CC基因型（分别为OR = 0.70， = 0.02和OR = 0.67， = 0.01）与PTC风险降低相关。rs16940的AG基因型（OR = 0.67， = 0.01）以及rs799917和rs1799949的AG基因型（均为OR = 0.70， = 0.02）降低了PTC风险。 的单倍型1 [rs8176318（C）-rs1799966（T）-rs799917（G）-rs16940（A）-rs1799949（G）] ± （OR = 0.69， = 0.02）和单倍型2 [rs8176318（A）-rs1799966（C）-rs799917（A）-rs
