Van Aelst Fabienne, Van Gool Bart, Van Damme Nancy, Poirel Hélène A
Cancer Center, Sciensano, 1050 Brussels, Belgium.
Belgian Cancer Registry, 1210 Brussels, Belgium.
Cancers (Basel). 2025 May 1;17(9):1543. doi: 10.3390/cancers17091543.
: This population-based study examined epidemiological trends of primary cancers in adolescents and young adults (AYAs) to enhance the understanding of the specific spectrum of cancers impacting AYAs in Belgium. : Data on incidence, prevalence, mortality, and survival were obtained from the Belgian Cancer Registry (2004-2020, N = 43,535). (A)APC statistics were compared with children (5-14 years) and adults (40-49 years). : Cancer incidence increased by 0.4% annually from 66 to 80 per 100,000 person-years (ESR2013) but stabilised after 2015, except for Hodgkin lymphoma, chronic myeloid neoplasms, and testicular and breast cancer, which continued to rise. Mortality decreased by 1% annually, from 10 to 7 per 100,000 person-years (2004-2019). Five-year relative survival (RS) was 87% but remained low for certain cancers, including ovary (78%), central nervous system (67%), precursor haematopoietic neoplasms (64%), gastrointestinal (excl. colorectal) (49%), and lung-bronchus-trachea cancers (42%). : From 2004-2020, the cancer burden among AYAs in Belgium increased due to improved survival, while incidence stabilised after 2015. Five-year RS exceeds 80% overall but remains lower for some cancers compared to children (e.g., precursor haematopoietic neoplasms) or older adults (e.g., breast cancer, sarcoma). The Belgian epidemiological trends align with those in neighbouring countries (Netherlands, France, Germany).
这项基于人群的研究调查了青少年和青年（AYA）原发性癌症的流行病学趋势，以加深对影响比利时AYA的特定癌症谱的理解。从比利时癌症登记处（2004 - 2020年，N = 43,535）获取了发病率、患病率、死亡率和生存率数据。（A）将年龄别发病率（APC）统计数据与儿童（5 - 14岁）和成年人（40 - 49岁）进行了比较。癌症发病率从每10万人年66例增加到80例，年增长率为0.4%（ESR2013），但在2015年后趋于稳定，不过霍奇金淋巴瘤、慢性髓系肿瘤以及睾丸癌和乳腺癌继续上升。死亡率每年下降1%，从每10万人年10例降至7例（2004 - 2019年）。五年相对生存率（RS）为87%，但某些癌症的生存率仍然较低，包括卵巢癌（78%）、中枢神经系统癌（67%）、造血前体肿瘤（64%）、胃肠道（不包括结直肠癌）癌（49%）以及肺 - 支气管 - 气管癌（42%）。从2004年到2020年，由于生存率提高，比利时AYA的癌症负担有所增加，而发病率在2015年后趋于稳定。总体五年RS超过80%，但与儿童（如造血前体肿瘤）或老年人（如乳腺癌、肉瘤）相比，某些癌症的生存率仍然较低。比利时的流行病学趋势与邻国（荷兰、法国、德国）一致。
