van der Meer Daniël J, Karim-Kos Henrike E, van der Mark Marianne, Aben Katja K H, Bijlsma Rhodé M, Rijneveld Anita W, van der Graaf Winette T A, Husson Olga
Department of Psychosocial Research and Epidemiology (PSOE), Netherlands Cancer Institute (NKI), 1066 CX Amsterdam, The Netherlands.
Netherlands Comprehensive Cancer Organisation (IKNL), 3511 DT Utrecht, The Netherlands.
Cancers (Basel). 2020 Nov 18;12(11):3421. doi: 10.3390/cancers12113421.
Adolescent and young adult (AYA) cancer patients, aged 15-39 years at primary cancer diagnosis, form a distinct, understudied, and underserved group in cancer care. This study aimed to assess long-term trends in incidence, survival, and mortality of AYA cancer patients within the Netherlands. Data on all malignant AYA tumours diagnosed between 1990-2016 ( = 95,228) were obtained from the Netherlands Cancer Registry. European age-standardised incidence and mortality rates with average annual percentage change (AAPC) statistics and five-year relative survival rates were calculated. The overall cancer incidence increased from 54.6 to 70.3 per 100,000 person-years (AAPC: +1.37%) between 1990-2016, and increased for both sexes individually and for most cancer types. Five-year relative survival overall improved from 73.7% in 1990-1999 to 86.4% in 2010-2016 and improved for both sexes and most cancer types. Survival remained poor (<60%) for rhabdomyosarcoma, lung, stomach, liver, bladder, and pancreatic carcinomas, among others. Mortality rates among male AYAs overall declined from 10.8 to 6.6 (AAPC: -1.64%) and from 14.4 to 10.1 per 100,000 person-years (AAPC: -1.81%) for female AYAs since 1990. Mortality rates remained unchanged for male AYAs aged 20-24 and 25-29 years. In conclusion, over the past three decades, there has been a considerable increase in cancer incidence among AYAs in the Netherlands. Meanwhile, the survival improved and the mortality overall declined. Survival at five-years now well exceeds above 80%, but did not do so for all cancer types.
青少年及青年（AYA）癌症患者在初次诊断癌症时年龄为15至39岁，在癌症护理领域中是一个独特的、研究不足且服务欠缺的群体。本研究旨在评估荷兰AYA癌症患者的发病率、生存率和死亡率的长期趋势。从荷兰癌症登记处获取了1990年至2016年间诊断出的所有恶性AYA肿瘤的数据（n = 95,228）。计算了欧洲年龄标准化发病率和死亡率以及平均年度百分比变化（AAPC）统计数据和五年相对生存率。1990年至2016年间，总体癌症发病率从每10万人年54.6例增至70.3例（AAPC：+1.37%），男性和女性个体以及大多数癌症类型的发病率均有所上升。总体五年相对生存率从1990年至1999年的73.7%提高到2010年至2016年的86.4%，男性和女性以及大多数癌症类型的生存率均有所提高。横纹肌肉瘤、肺癌、胃癌、肝癌、膀胱癌和胰腺癌等癌症的生存率仍然较低（<60%）。自1990年以来，男性AYA的死亡率总体从每10万人年10.8例降至6.6例（AAPC：-1.64%），女性AYA从每10万人年14.4例降至10.1例（AAPC：-1.81%）。20至24岁和25至29岁男性AYA的死亡率保持不变。总之，在过去三十年中，荷兰AYA的癌症发病率有了显著增加。与此同时，生存率提高，总体死亡率下降。现在五年生存率已远超过80%，但并非所有癌症类型都是如此。
