Waring R H, Mitchell S C
Xenobiotica. 1985 Jun;15(6):459-68. doi: 10.3109/00498258509045019.
The presence of a polypeptide conjugate fraction in the urine of young calves after oral dosing with phenothiazine has been confirmed. Four different polypeptide conjugates, containing up to six amino acids attached to phenothiazine or leucophenothiazone via the carboxyl terminal of the chain, have been isolated, characterized and sequenced. In addition, several minor polypeptide conjugates have been observed. The literature pertaining to polypeptide conjugates of drugs has been reviewed and the importance of this metabolic route in neonatal animals discussed.
已证实给幼牛口服吩噻嗪后，其尿液中存在一种多肽共轭物组分。现已分离、鉴定并测序了四种不同的多肽共轭物，这些共轭物含有通过链的羧基末端连接到吩噻嗪或亮吩噻嗪酮上的多达六个氨基酸。此外，还观察到了几种次要的多肽共轭物。已对与药物多肽共轭物相关的文献进行了综述，并讨论了这种代谢途径在新生动物中的重要性。
