Mitchell S C, Waring R H
Drug Metab Dispos. 1979 Nov-Dec;7(6):399-403.
The metabolism of phenothiazine was studied in the guinea pig. In the adult animal after 24 hr, about 7% of the administered dose was found in feces, with traces of the sulfoxide and phenothiazone. Small amounts of all these compounds also were found in urine, with leucophenothiazone sulfate (approximately 12%) and a metabolite identified as phenothiazine N-glucuronide (approximately 22%). This latter compound was also present in bile. Both phenothiazine and its sulfoxide were retained in body tissues for a long time, about 85% of the dose being excreted after 7 days. In neonatal animals, phenothiazine, with up to 12% of the sulfoxide together with traces of leucophenothiazone, phenothiazone, and thionol was excreted in urine.
在豚鼠身上研究了吩噻嗪的代谢情况。在成年动物中，给药24小时后，约7%的给药剂量在粪便中被发现，同时伴有痕量的亚砜和吩噻嗪酮。在尿液中也发现了少量的所有这些化合物，其中包括硫酸白吩噻嗪（约12%）和一种被鉴定为吩噻嗪N-葡萄糖醛酸苷的代谢物（约22%）。后一种化合物也存在于胆汁中。吩噻嗪及其亚砜在身体组织中保留了很长时间，约85%的剂量在7天后排出。在新生动物中，吩噻嗪、高达12%的亚砜以及痕量的白吩噻嗪、吩噻嗪酮和硫蒽酚随尿液排出。
