Rahman Md Sharifur, Qi Guangyan, Li Cheng, Li Yonghui, Wang Weiqun, Atala Anthony, Sun Xiuzhi Susan
Department of Biological and Agricultural Engineering, Kansas State University, Manhattan, KS 66506, USA.
Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
Foods. 2025 May 6;14(9):1633. doi: 10.3390/foods14091633.
Wheat bran, rich in phenolic compounds like ferulic acid, possesses notable antioxidant properties that may contribute to cancer treatment strategies. This study examined the effects of hydrolyzed arabinoxylan oligomers (HAOs) linked with ferulic acid from hard wheat bran on three human cancer cell lines: colon cancer (SW480), liver cancer (HepG2), and cervical cancer (HeLa). Cells were cultured in a three-dimensional (3D) 0.5% PGS matrix and exposed to varying concentrations (100, 500, and 1000 μg/mL) of wheat bran antioxidants (WBA) extracts. Results show that WBA inhibited growth of SW480 cells, significantly reducing spheroid expansion and promoting dehydration. In contrast, HepG2 cells exhibited increased growth under WBA treatment, suggesting a non-toxic, growth-enhancing effect. No significant changes were observed in HeLa cell growth, with cell viability remaining high across all treatments. These findings highlight the selective influence of WBA on cancer cell behavior, underscoring its potential for targeted, personalized cancer therapies. This study provides valuable insights into the application of antioxidant-rich compounds for modulating specific cancer cell dynamics, paving the way for novel therapeutic approaches.
麦麸富含阿魏酸等酚类化合物，具有显著的抗氧化特性，可能有助于癌症治疗策略。本研究检测了与硬粒小麦麸中的阿魏酸相连的水解阿拉伯木聚糖低聚物（HAOs）对三种人类癌细胞系的影响：结肠癌细胞（SW480）、肝癌细胞（HepG2）和宫颈癌细胞（HeLa）。细胞在三维（3D）0.5% PGS基质中培养，并暴露于不同浓度（100、500和1000 μg/mL）的麦麸抗氧化剂（WBA）提取物中。结果表明，WBA抑制了SW480细胞的生长，显著减少了球体扩张并促进了脱水。相比之下，HepG2细胞在WBA处理下表现出增长增加，表明具有无毒、促进生长的作用。HeLa细胞生长未观察到显著变化，所有处理下细胞活力均保持较高水平。这些发现突出了WBA对癌细胞行为的选择性影响，强调了其在靶向、个性化癌症治疗中的潜力。本研究为富含抗氧化剂的化合物调节特定癌细胞动态的应用提供了有价值的见解，为新型治疗方法铺平了道路。
