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支气管类癌中的椎体转移:一例罕见病例报告及超过3年的随访与文献复习

Vertebral Metastasis in a Bronchial Carcinoid: A Rare Case Report with More than 3-Year Follow-Up and Review of the Literature.

作者信息

Biz Carlo, Rodà Maria Grazia, Mori Fabiana, Costa Lorenzo, Gabrieli Joseph Domenico, Causin Francesco, Ruggieri Pietro

机构信息

Orthopedics and Orthopedic Oncology, Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padova, Via Giustiniani 3, 35128 Padova, Italy.

Neuroradiology Unit, Padua University Hospital, Via Giustiniani 2, 35128 Padova, Italy.

出版信息

Diagnostics (Basel). 2025 Apr 28;15(9):1128. doi: 10.3390/diagnostics15091128.

DOI:10.3390/diagnostics15091128
PMID:40361946
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12071200/
Abstract

Skeletal metastases from carcinoid tumours are extremely rare. Their correct diagnosis is a challenging problem for clinicians and pathologists, with important clinical implications for patients. In most cases, examination for the possible presence of skeletal metastases is initiated only when patients present symptoms suggestive of skeletal metastases. In this paper, the authors present the case of a middle-aged woman suffering from back pain due to a bronchial carcinoid that metastasised to the spine. We managed skeletal metastases with vertebroplasty and achieved excellent results and the complete remission of symptoms six months after the procedure. The relevance of this case report is that it highlights the importance of correctly diagnosing and treating these rare lesions to improve the quality of life of metastatic oncologic patients.

摘要

类癌肿瘤的骨转移极为罕见。其正确诊断对临床医生和病理学家而言是一个具有挑战性的问题,对患者具有重要的临床意义。在大多数情况下,仅当患者出现提示骨转移的症状时,才会开始检查是否可能存在骨转移。在本文中,作者介绍了一名中年女性的病例,该患者因支气管类癌转移至脊柱而患有背痛。我们通过椎体成形术治疗骨转移,取得了优异的效果,术后六个月症状完全缓解。本病例报告的意义在于,它强调了正确诊断和治疗这些罕见病变对于改善转移性肿瘤患者生活质量的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/976e/12071200/88a35b3bd451/diagnostics-15-01128-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/976e/12071200/a2d9c68fbf50/diagnostics-15-01128-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/976e/12071200/2924ef7042f7/diagnostics-15-01128-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/976e/12071200/7bb55ac18d4e/diagnostics-15-01128-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/976e/12071200/5a618eb3cd32/diagnostics-15-01128-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/976e/12071200/e91d71746f4c/diagnostics-15-01128-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/976e/12071200/88a35b3bd451/diagnostics-15-01128-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/976e/12071200/a2d9c68fbf50/diagnostics-15-01128-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/976e/12071200/2924ef7042f7/diagnostics-15-01128-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/976e/12071200/7bb55ac18d4e/diagnostics-15-01128-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/976e/12071200/5a618eb3cd32/diagnostics-15-01128-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/976e/12071200/e91d71746f4c/diagnostics-15-01128-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/976e/12071200/88a35b3bd451/diagnostics-15-01128-g006.jpg

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本文引用的文献

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Lung Carcinoids: A Comprehensive Review for Clinicians.肺类癌:给临床医生的全面综述
Cancers (Basel). 2023 Nov 16;15(22):5440. doi: 10.3390/cancers15225440.
2
Gender-related differences in patients with carcinoid syndrome: new insights from an Italian multicenter cohort study.性别相关的类癌综合征患者差异:来自意大利多中心队列研究的新见解。
J Endocrinol Invest. 2024 Apr;47(4):959-971. doi: 10.1007/s40618-023-02213-1. Epub 2023 Oct 14.
3
The Formation of NETs and Their Mechanism of Promoting Tumor Metastasis.中性粒细胞胞外陷阱的形成及其促进肿瘤转移的机制。
J Oncol. 2023 Mar 11;2023:7022337. doi: 10.1155/2023/7022337. eCollection 2023.
4
Comprehensive treatment outcomes of giant cell tumor of the spine: A retrospective study.脊柱巨细胞瘤的综合治疗结果:一项回顾性研究。
Medicine (Baltimore). 2022 Aug 12;101(32):e29963. doi: 10.1097/MD.0000000000029963.
5
Rare Bone Metastasis of Neuroendocrine Tumors of Unknown Origin: A Case Report and Literature Review.不明来源神经内分泌肿瘤罕见骨转移:病例报告及文献复习。
Orthop Surg. 2022 Oct;14(10):2766-2775. doi: 10.1111/os.13384. Epub 2022 Jul 20.
6
Pulmonary Neuroendocrine Cells and Small Cell Lung Carcinoma: Immunohistochemical Study Focusing on Mechanisms of Neuroendocrine Differentiation.肺神经内分泌细胞与小细胞肺癌:聚焦神经内分泌分化机制的免疫组织化学研究
Acta Histochem Cytochem. 2022 Jun 29;55(3):75-83. doi: 10.1267/ahc.22-00031. Epub 2022 May 24.
7
Pulmonary neuroendocrine tumours and somatostatin receptor status: an assessment of unlicensed use of somatostatin analogues in the clinical practice.肺部神经内分泌肿瘤与生长抑素受体状态:评估生长抑素类似物在临床实践中的未经许可使用。
ESMO Open. 2022 Jun;7(3):100478. doi: 10.1016/j.esmoop.2022.100478. Epub 2022 May 4.
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Molecular Pathology of Well-Differentiated Pulmonary and Thymic Neuroendocrine Tumors: What Do Pathologists Need to Know?肺和胸腺神经内分泌肿瘤的分子病理学:病理学家需要了解什么?
Endocr Pathol. 2021 Mar;32(1):154-168. doi: 10.1007/s12022-021-09668-z. Epub 2021 Feb 27.
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