Alster Piotr, Madetko-Alster Natalia
Department of Neurology, Medical University of Warsaw, Kondratowicza 8, 03-242 Warsaw, Poland.
Int J Mol Sci. 2025 Apr 22;26(9):3927. doi: 10.3390/ijms26093927.
Progressive supranuclear palsy (PSP) is a neurodegenerative disease, classified as an atypical Parkinsonian syndrome, that has been pathologically and clinically defined. The histopathological aspects of the disease include tufted astrocytes, while the clinical features involve oculomotor dysfunction, postural instability, akinesia, cognitive impairment, and language difficulties. Although PSP is generally considered a sporadic disease, interest is growing in its genetics, with contemporary research focusing on familial backgrounds and neuroinflammation. Indeed, microglial activation and other inflammatory mechanisms of PSP pathogenesis have been extensively analyzed using genetic examinations to identify the factors impacting neurodegeneration. As such, this review aims to elaborate on recent findings in this field.
进行性核上性麻痹（PSP）是一种神经退行性疾病，归类为非典型帕金森综合征，已在病理和临床方面得到明确界定。该疾病的组织病理学特征包括簇状星形胶质细胞，而临床特征则涉及眼球运动功能障碍、姿势不稳、运动不能、认知障碍和语言困难。尽管PSP通常被认为是一种散发性疾病，但人们对其遗传学的兴趣与日俱增，当代研究聚焦于家族背景和神经炎症。事实上，已通过基因检测广泛分析了PSP发病机制中的小胶质细胞激活及其他炎症机制，以确定影响神经退行性变的因素。因此，本综述旨在详细阐述该领域的最新研究发现。
