Valencia Sandra, Zuluaga Martha, Florian Pérez María Cristina, Montoya-Quintero Kevin Fernando, Candamil-Cortés Mariana S, Robledo Sebastian
Centro de Bioinformática y Biología Computacional de Colombia-BIOS, Grupo de Investigación-BIOS, Parque los Yarumos, Manizales 170002, Colombia.
Departamento de Ciencias Básicas de la Salud, Facultad de Ciencias para la Salud, Universidad de Caldas, Calle 65 # 26-10, Manizales 170004, Colombia.
Int J Mol Sci. 2025 Apr 26;26(9):4112. doi: 10.3390/ijms26094112.
The gut microbiome plays a vital role in human health, functioning as a metabolic organ that influences nutrient absorption and overall well-being. With growing evidence that dietary interventions can modulate the microbiome and improve health, this review examines whether healthcare systems should prioritize personalized microbiome-targeted therapies, such as probiotics, prebiotics, and microbiota transplants, over traditional pharmaceutical treatments for chronic diseases like obesity, diabetes, cardiovascular risk, and inflammatory conditions. A systematic review using Web of Science and Scopus databases was conducted, followed by a scientometric analysis. Key metabolic pathways, such as dietary fiber fermentation and short-chain fatty acid production, were explored, focusing on their impact on lipid and glucose metabolism. The interactions between microbial metabolites and the immune system were also investigated. Dietary interventions, including increased fiber and probiotic intake, show potential for addressing dysbiosis linked to conditions, such as type 2 diabetes, obesity, and autoimmune diseases. The review emphasizes the need to incorporate microbiome modulation strategies into clinical practice and research, calling for a multidisciplinary approach that integrates nutrition, microbiology, and biochemistry to better understand the gut microbiome's complex role in health.
肠道微生物群在人类健康中起着至关重要的作用，它作为一个代谢器官，影响营养物质的吸收和整体健康状况。随着越来越多的证据表明饮食干预可以调节微生物群并改善健康，本综述探讨了医疗保健系统是否应优先考虑针对微生物群的个性化疗法，如益生菌、益生元及微生物群移植，而非针对肥胖、糖尿病、心血管疾病风险和炎症性疾病等慢性病的传统药物治疗。我们使用科学网和Scopus数据库进行了系统综述，随后进行了科学计量分析。研究了关键代谢途径，如膳食纤维发酵和短链脂肪酸生成，重点关注它们对脂质和葡萄糖代谢的影响。还研究了微生物代谢产物与免疫系统之间的相互作用。饮食干预，包括增加纤维和益生菌的摄入量，显示出解决与2型糖尿病、肥胖症和自身免疫性疾病等病症相关的生态失调问题的潜力。该综述强调需要将微生物群调节策略纳入临床实践和研究，呼吁采用多学科方法，整合营养、微生物学和生物化学，以更好地理解肠道微生物群在健康中的复杂作用。
