Zhao Mengxiao, Chen Liwei, Chen Yuhang, Yang Xuecheng, Feng Xuemei, Yang Dongliang, Zheng Xin, Liu Jia
Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Institute of Infectious Diseases and Immunity, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Int J Mol Sci. 2025 May 2;26(9):4341. doi: 10.3390/ijms26094341.
CD100/SEMA4D, a member of the Semaphorin family, is a transmembrane glycoprotein that regulates neurogenesis, immune modulation, and angiogenesis, with its immunoregulatory roles having attracted considerable attention. It is dynamically expressed on the surface of diverse immune cells-including T cells, B cells, dendritic cells (DCs), and natural killer (NK) cells-with expression levels modulated by cellular activation states. CD100 exists in two functional forms: membrane-bound CD100 (mCD100) and soluble CD100 (sCD100) generated via proteolytic cleavage. Recent studies have highlighted its critical involvement in viral infectious diseases. This review systematically summarizes the molecular characteristics, expression patterns, and regulatory functions of CD100 on different immune cells, and discusses its role in viral infectious diseases and its clinical application potential.
CD100/SEMA4D是信号素家族的成员，是一种跨膜糖蛋白，可调节神经发生、免疫调节和血管生成，其免疫调节作用已引起广泛关注。它在多种免疫细胞表面动态表达，包括T细胞、B细胞、树突状细胞（DC）和自然杀伤（NK）细胞，其表达水平受细胞激活状态调节。CD100以两种功能形式存在：膜结合型CD100（mCD100）和通过蛋白水解切割产生的可溶性CD100（sCD100）。最近的研究突出了其在病毒感染性疾病中的关键作用。本文综述系统总结了CD100在不同免疫细胞上的分子特征、表达模式和调节功能，并探讨了其在病毒感染性疾病中的作用及其临床应用潜力。
