Cellular Receptors Laboratory, Cantacuzino National Institute of Research and Development for Microbiology and Immunology, Bucharest, Romania.
Autoimmunity. 2011 Aug;44(5):427-36. doi: 10.3109/08916934.2010.541171. Epub 2011 Jan 19.
It was suggested that the immune system plays an important role at least in the amplification of the main elements in systemic sclerosis (SSc), an autoimmune disease with an incompletely elucidated pathogenesis. Elucidation of the mechanisms involved in the interaction between T and B cells, major players of the immune system, could contribute to a better understanding of some of clinical and pathological manifestations of SSc. Recently, abnormalities in Semaphorin 4D (Sema4D/CD100) or CD72, two contrareceptors involved in T and B cells cooperation, were associated with autoimmunity. Therefore, we investigated CD100 and CD72 expression level on T and B cells in attempting to establish their role in SSc pathogenesis. The results revealed augmented percentages of CD100(high) T and B cells, significantly increased expression of CD100 on CD4(+) T cells and frequently detectable levels of soluble CD100 in SSc patient sera compared to healthy donors. In SSc, CD100 dysregulations were associated with anti-Scl70 antibodies production, disease type, thickening of skin, disease duration, or with active inflammation processes. In consequence, dysregulations in CD100 expression and release could play a role in SSc development and/or maintenance.
有人提出，免疫系统至少在全身性硬皮病（SSc）的主要因素的放大中发挥重要作用，这是一种发病机制尚未完全阐明的自身免疫性疾病。阐明参与 T 细胞和 B 细胞之间相互作用的机制，这是免疫系统的主要参与者之一，可以帮助我们更好地理解 SSc 的一些临床和病理表现。最近，Semaphorin 4D（Sema4D/CD100）或 CD72 的异常，这两种涉及 T 和 B 细胞合作的反向受体，与自身免疫有关。因此，我们研究了 T 和 B 细胞上 CD100 和 CD72 的表达水平，试图确定它们在 SSc 发病机制中的作用。结果显示，与健康供体相比，SSc 患者的 T 和 B 细胞中 CD100（高）的百分比增加，CD4（+）T 细胞上 CD100 的表达显著增加，并且在 SSc 患者的血清中经常可检测到可溶性 CD100。在 SSc 中，CD100 的失调与抗 Scl70 抗体的产生、疾病类型、皮肤增厚、疾病持续时间或活跃的炎症过程有关。因此，CD100 表达和释放的失调可能在 SSc 的发展和/或维持中发挥作用。
