Schurr Avital
Department of Anesthesiology and Perioperative Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Int J Mol Sci. 2025 May 7;26(9):4429. doi: 10.3390/ijms26094429.
Ever since the monocarboxylate, lactate, was shown to be more than a useless end-product of anaerobic glycolysis, the members of the brain energy metabolism research community are divided by two issues: First, could lactate replace glucose as the oxidative mitochondrial energy substrate? Second, should glycolysis continue to be divided into aerobic and anaerobic pathways? This opinion paper examined both the history and the reasons for this division and offered a unifying solution. Some readers may find this paper somewhat slanted, although many aspects of my opinion are backed, whenever possible, by data.
自从单羧酸乳酸被证明不仅仅是无氧糖酵解的无用终产物以来，脑能量代谢研究领域的成员在两个问题上存在分歧：第一，乳酸能否替代葡萄糖作为线粒体氧化能量底物？第二，糖酵解是否应继续分为有氧和无氧途径？这篇观点论文审视了这种分歧的历史和原因，并提出了一个统一的解决方案。一些读者可能会觉得这篇论文有些片面，尽管我的观点在可能的情况下都有数据支持。
