Bao Yuzhang, Wang Chenyu, Zhang Na, Li Jie, Yuan Song, Yu Liju, Di Bin, Liu Yang
National Institutes for Food and Drug Control, Beijing 102629, China.
School of Pharmaceutical Sciences, China Pharmaceutical University, Nanjing 211100, China.
Molecules. 2025 Apr 25;30(9):1906. doi: 10.3390/molecules30091906.
Chromatography-mass spectrometry typically requires a time-consuming and costly pretreatment to detect illegal additives in cosmetics. Retinoic acid is classified as a prohibited additive in cosmetics by the European Union and China. Therefore, a rapid and convenient method is needed for its detection. In this study, a method for detecting retinoic acid using Reactive Paper Spray Ionization Mass Spectrometry was developed. '-dimethylpiperazine was used as the derivatization reagent due to its ability to react with carboxyl functional groups at room temperature. Our results indicate that the derivatized retinoic acid compounds obtained using this method exhibited good linearity within the range of 0.0005~0.1 μg·mL, achieving a limit of detection of 0.107 ng·mL.
色谱 - 质谱联用技术通常需要耗时且昂贵的预处理来检测化妆品中的非法添加剂。视黄酸在欧盟和中国被列为化妆品中的禁用添加剂。因此，需要一种快速便捷的检测方法。在本研究中，开发了一种使用反应性纸喷雾电离质谱法检测视黄酸的方法。由于其能够在室温下与羧基官能团反应，因此使用N,N'-二甲基哌嗪作为衍生试剂。我们的结果表明，使用该方法获得的衍生视黄酸化合物在0.0005~0.1 μg·mL范围内表现出良好的线性，检测限达到0.107 ng·mL。
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