Ahmed Ahmed, Bezrukov Andrey, Sensharma Debobroto, O'Malley Ciaran, Zaworotko Michael J, Tiana Davide, Papatriantafyllopoulou Constantina
SSPC Research Ireland Centre for Pharmaceuticals, Ireland.
School of Biological and Chemical Sciences, College of Science and Engineering, University of Galway, H91 TK33 Galway, Ireland.
Molecules. 2025 Apr 29;30(9):1968. doi: 10.3390/molecules30091968.
The development of drug carriers with efficient absorption and controlled delivery properties is crucial for advancing medical treatments. Metal-organic frameworks (MOFs) with tunable porosity and a large surface area represent a promising class of materials for this application. Among them, stands out as a biocompatible MOF that exhibits exceptionally high doxorubicin (Dox) absorption (1995 mg dox/g ) and pH-controlled release properties. In this study, we report the synthesis and characterisation of multivariate MOFs (), which are analogues of that maintain the same topology while incorporating different functional groups within their framework. Eight new MOFs have been synthesised through in situ reactions of the corresponding 4-aminobenzoic acid derivative with 4-formylbenzoic acid. The compounds were thoroughly characterised using a range of techniques, including powder X-ray diffraction, infrared spectroscopy, H-NMR, and single-crystal X-ray crystallography. The experimental ratio of the reagents and ligand precursors for the synthesis of MOFs matched the ratio of the linkers in the final products. These structures incorporate additional functional groups, such as methyl and hydroxyl, in varying ratios. Computational modelling was used to provide further insight into the crystal structure of the MOFs, revealing a random distribution of the functional groups in the framework. The Dox absorption and release capacity of all analogues were studied, and the results revealed that all analogues displayed high drug absorption in the range of 1234-1995 mg Dox/g MOF. Furthermore, the absorption and release rates of the drug are modulated by the ratio of functional groups, providing a promising approach for controlling drug delivery properties in MOFs.
开发具有高效吸收和可控释放特性的药物载体对于推进医学治疗至关重要。具有可调孔隙率和大表面积的金属有机框架（MOF）是适用于此应用的一类很有前景的材料。其中，作为一种生物相容性MOF脱颖而出，它表现出极高的阿霉素（Dox）吸收量（1995毫克阿霉素/克）和pH值控制释放特性。在本研究中，我们报告了多变量MOF（）的合成与表征，它是 的类似物，在保持相同拓扑结构的同时，其框架内引入了不同的官能团。通过相应的4-氨基苯甲酸衍生物与4-甲酰基苯甲酸的原位反应合成了八种新的 MOF。使用一系列技术对这些化合物进行了全面表征，包括粉末X射线衍射、红外光谱、H-NMR和单晶X射线晶体学。合成MOF的试剂和配体前体的实验比例与最终产物中连接体的比例相匹配。这些结构以不同比例包含额外的官能团，如甲基和羟基。使用计算模型进一步深入了解MOF的晶体结构，揭示了框架中官能团的随机分布。研究了所有类似物的Dox吸收和释放能力，结果表明所有类似物在1234 - 1995毫克Dox/克MOF范围内均表现出高药物吸收。此外，药物的吸收和释放速率受官能团比例的调节，为控制MOF中的药物递送特性提供了一种有前景的方法。
