Meyer M W, Smith K A, Klassen A C
Stroke. 1977 Mar-Apr;8(2):197-201. doi: 10.1161/01.str.8.2.197.
Blood flow to bilateral tissues (cranial and extracranial) was studied by means of the particle distribution method in two groups of anesthetized dogs (five using 25-mu radioactive microspheres, six using 15-mu microspheres) and five anesthetized stumptail Macaques monkeys (8-mj spheres) during unilateral sympathetic stimulation. The stimulatory parameters were adjusted to produce maximum pupillary dilatation. In the five dogs hemispheric and regional cerebral blood flow decreased but not significantly. Flow to the extracranial tissues decreased 82%. Hemispheric brain blood flow averaged 0.70 ml/min/gm for Paco2 of 40 mm Hg. In the six dogs sympathetic stimulation did not significantly decrease cerebral blood flow but decreased flow to extracranial tissues (72.3%). At an average Paco2 of 33.2 mm Hg, hemispheric blood flow to the unstimulated side averaged 0.51 ml/min/gm. In the five monkeys findings were essentially the same as those observed in the dogs. The hemispheric blood flow averaged 0.36 ml/min/gm on the nonstimulated side for an average Paco2 of 36.6 mm Hg. Under the conditions studied, electrical stimulation of the cervical sympathetic nerves does not appear to modify regional or total brain blood flow in dogs and Macaques monkeys. The vascular response in oral and other extracranial tissues is very dramatic, however.
在两组麻醉犬（5只使用25微米放射性微球，6只使用15微米微球）和5只麻醉断尾猕猴（8微米微球）中，采用微粒分布法研究了单侧交感神经刺激期间双侧组织（颅内和颅外）的血流情况。刺激参数经调整以产生最大瞳孔散大。在5只犬中，半球和局部脑血流减少，但不显著。颅外组织的血流减少了82%。对于40毫米汞柱的动脉血二氧化碳分压（Paco2），半球脑血流平均为0.70毫升/分钟/克。在6只犬中，交感神经刺激未显著降低脑血流，但降低了颅外组织的血流（72.3%）。在平均Paco2为33.2毫米汞柱时，未受刺激侧的半球血流平均为0.51毫升/分钟/克。在5只猕猴中，结果与在犬中观察到的基本相同。对于平均Paco2为36.6毫米汞柱，未受刺激侧的半球血流平均为0.36毫升/分钟/克。在所研究的条件下，颈交感神经的电刺激似乎不会改变犬和猕猴的局部或全脑血流。然而，口腔和其他颅外组织的血管反应非常显著。
