Carnes-Vendrell Anna, Piñol-Ripoll Gerard, Ariza Mar, Cano Neus, Segura Barbara, Junque Carme, Béjar Javier, Barrue Cristian, Garolera Maite
Cognitive Disorders Unit, Cognition and Behaviour Study Group, Hospital Universitari Santa Maria, 25198 Lleida, Spain.
Clinical Research Group for Brain, Cognition and Behaviour, Consorci Sanitari de Terrassa, 08227 Terrassa, Spain.
J Clin Med. 2025 Apr 23;14(9):2911. doi: 10.3390/jcm14092911.
: In the present study, we aimed (i) to describe the personality traits of a cohort of post-COVID-19 condition (PCC) patients compared with a healthy control (HC) group, (ii) to evaluate the relationship between sleep quality and personality traits, and (iii) to investigate whether this relationship differs according to disease severity. : We included 599 participants from the Nautilus Project (ClincalTrials.gov IDs: NCT05307549 and NCT05307575) with an age range from 20 to 65 years old. Of 599 participants, 280 were nonhospitalized (mild PCC), 87 were hospitalized (hospitalized PCC), 98 were in the PCC-ICU, and 134 were in the HC group. We assessed sleep quality with the Pittsburgh Sleep Quality Index (PSQI) and personality traits with the NEO Five-Factor Inventory (NEO FFI). : We found that mild-PCC patients had higher scores of neuroticism than HCs ( < 0.001) and ICU-PCC patients did ( = 0.020). The higher the neuroticism score was, the higher the total PSQI score (B 0.162; < 0.001), the worse the sleep latency (B 0.049; < 0.001), the greater the degree of sleep disturbance (B 0.060; < 0.001), the greater the use of sleeping medication (B 0.035; = 0.033), and the greater the incidence of daytime disturbances (B 0.065; < 0.001) among the PCC patients. High neuroticism is also an indicator of worse sleep quality in mild-PCC (t = 3.269; 0.001) and hospitalized-PCC (t = 6.401; < 0.001) patients and HCs (t = 4.876; < 0.001) but not in ICU-PCC patients. : Although neuroticism affected sleep quality in both the PCC patients and HCs, the clinical implications and magnitude of the relationship were more significant in the PCC group. Specific and multidimensional interventions are needed to treat sleep problems in this population, and the influence of their personality traits should be considered.
在本研究中，我们旨在：（i）描述一组新冠后状况（PCC）患者与健康对照组（HC）相比的人格特质；（ii）评估睡眠质量与人格特质之间的关系；（iii）调查这种关系是否因疾病严重程度而异。我们纳入了来自鹦鹉螺项目（ClinicalTrials.gov标识符：NCT05307549和NCT05307575）的599名参与者，年龄范围为20至65岁。在这599名参与者中，280名未住院（轻度PCC），87名住院（住院PCC），98名在PCC-ICU，134名在HC组。我们用匹兹堡睡眠质量指数（PSQI）评估睡眠质量，用大五人格问卷（NEO FFI）评估人格特质。我们发现，轻度PCC患者的神经质得分高于HC组（<0.001），ICU-PCC患者也是如此（=0.020）。神经质得分越高，PCC患者的PSQI总分越高（B 0.162；<0.001），睡眠潜伏期越差（B 0.049；<0.001），睡眠干扰程度越大（B 0.060；<0.001），使用睡眠药物的情况越多（B 0.035；=0.033），白天干扰的发生率越高（B 0.065；<0.001）。高神经质也是轻度PCC（t = 3.269；0.001）、住院PCC（t = 6.401；<0.001）患者和HC组（t = 4.876；<0.001）睡眠质量较差的一个指标，但在ICU-PCC患者中并非如此。虽然神经质在PCC患者和HC组中均影响睡眠质量，但这种关系的临床意义和程度在PCC组中更为显著。需要采取针对性的多维干预措施来治疗该人群的睡眠问题，并且应考虑其人格特质的影响。
