Morozova Natalia Sergeevna, Elovskaya Alina Alekseevna, Maslikova Ekaterina Andreevna, Sevbitov Andrey Vladimirovich, Timoshina Maria Dmitrievna, Amkhadova Malkan Abdrashidovna, Maltseva Larisa Dmitrievna, Velichko Ellina Valerievna, Danilova Elena Yur'evna, Morozova Olga Leonidovna
Department of Dental Diseases Propaedeutics, E.V. Borovsky Institute of Dentistry, I.M. Sechenov First Moscow State Medical University (Sechenov University), 117418 Moscow, Russia.
Department of Pediatric, Preventive Dentistry and Orthodontics, E.V. Borovsky Institute of Dentistry, I.M. Sechenov First Moscow State Medical University (Sechenov University), 121059 Moscow, Russia.
J Clin Med. 2025 Apr 24;14(9):2951. doi: 10.3390/jcm14092951.
: This study aimed to establish the regularities of changes in the content of matrix metalloproteinase 8 (MMP-8) and osteoprotegerin (OPG), the most well-known indicators of bone metabolism disorders, in the saliva of children with different severities of chronic kidney disease (CKD) who need orthodontic treatment. : The study of MMP-8 and OPG content in saliva was carried out in 76 children in need of orthodontic treatment, who were divided into equal groups (G) of 19 people: G1-children with congenital malformations of the urinary tract, acquired renal pathology, and CKD stage 1 and 2, receiving medical therapy, as well as more having a deep distal bite formed by mandibular micrognathia; G2-children with a terminal stage of CKD, receiving renal replacement therapy in the volume of hemodialysis, with a characteristic distal bite of different etiology; G3-children one year after kidney transplantation, with a tendency to form an open distal bite, associated to a greater extent with maxillary macrognathia. G4-practically healthy children without renal pathology stratified by sex and age. : It was found that the content of MMP-8 and OPG in the saliva of children with different CKD stages who needed orthodontic treatment was significantly higher than the G4. The maximum values of MMP-8 were registered in G2. An increase in OPG content in saliva was observed in the G1 and G3. : The identified changes in markers of mineral and bone disorders in the saliva of children with different stages of CKD show the possibility of their use as non-invasive predictive and prognostic markers for the diagnosis of preclinical stages of bone metabolic disorders.
本研究旨在确定基质金属蛋白酶8（MMP - 8）和骨保护素（OPG）含量的变化规律，这两种物质是骨代谢紊乱最知名的指标，研究对象为需要正畸治疗的不同严重程度慢性肾脏病（CKD）患儿的唾液。
对76名需要正畸治疗的儿童进行了唾液中MMP - 8和OPG含量的研究，这些儿童被平均分为19人的四组（G组）：G1组为患有泌尿系统先天性畸形、获得性肾脏疾病且处于CKD 1期和2期的儿童，他们正在接受药物治疗，并且由于下颌小颌畸形形成了较深的远中咬合；G2组为处于CKD终末期的儿童，正在接受血液透析量的肾脏替代治疗，具有不同病因的典型远中咬合；G3组为肾移植一年后的儿童，有形成开放性远中咬合的倾向，在更大程度上与上颌骨过大有关。G4组为无肾脏疾病的实际健康儿童，按性别和年龄分层。
研究发现，需要正畸治疗的不同CKD阶段患儿唾液中MMP - 8和OPG的含量显著高于G4组。G2组中MMP - 8的含量最高。G1组和G3组中唾液OPG含量有所增加。
不同CKD阶段患儿唾液中矿物质和骨代谢紊乱标志物的这些变化表明，它们有可能作为非侵入性预测和预后标志物用于诊断骨代谢紊乱的临床前期阶段。
