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下肢坏死性软组织感染的管理:显微外科重建与医院资源需求——来自三级转诊中心的病例系列

Managing Necrotizing Soft Tissue Infections of the Lower Limb: Microsurgical Reconstruction and Hospital Resource Demands-A Case Series from a Tertiary Referral Center.

作者信息

Karamitros Georgios, Grant Michael P, Henry Sharon, Lamaris Gregory A

机构信息

Division of Plastic and Reconstructive Surgery, R. Adams Cowley Shock Trauma Center, University of Maryland Medical Center, Baltimore, MD 21201, USA.

Department of Surgery, R. Adams Cowley Shock Trauma Center, University of Maryland Medical Center, Baltimore, MD 21201, USA.

出版信息

J Clin Med. 2025 Apr 26;14(9):2997. doi: 10.3390/jcm14092997.

Abstract

Necrotizing soft tissue infections (NSTIs) of the lower extremities represent a surgical emergency with high morbidity, complex reconstruction, and considerable healthcare demands. Free tissue transfer (FTT) is increasingly utilized for limb salvage in extensive soft tissue defects, yet its implications for hospital resource utilization remain unclear. This study aims to compare clinical outcomes and perioperative resource demands between FTT and local flap (LF) reconstruction in NSTI patients. A retrospective case series was conducted at a tertiary referral center between September 2022 and January 2025, including eight patients with NSTI of the lower extremity (FTT, = 4; LF, = 4). Demographic data, comorbidities, surgical timing, complication profiles, and resource utilization metrics-including operative duration, hospitalization length, and number of procedures-were analyzed. All FTT cases underwent preoperative CT angiography as part of institutional protocol. Mean time to definitive reconstruction was longer in the FTT group (17.25 vs. 8 days, = 0.15), reflecting staged infection control. FTT procedures demonstrated significantly longer operative times (331.75 vs. 170.25 minutes, = 0.015), but there was no significant difference in total hospital stay (34.75 vs. 27.71 days, = 0.65). No cases of flap loss or venous congestion were observed, and outcomes were optimized via delayed dangling protocols. : FTT is a viable and effective reconstructive modality for lower extremity NSTIs. Despite increased surgical complexity, FTT did not significantly increase hospital resource utilization, supporting its role in limb preservation among appropriately selected patients.

摘要

下肢坏死性软组织感染(NSTIs)是一种外科急症,具有高发病率、复杂的重建需求和巨大的医疗需求。在广泛的软组织缺损中,游离组织移植(FTT)越来越多地用于肢体挽救,但其对医院资源利用的影响仍不清楚。本研究旨在比较FTT和局部皮瓣(LF)重建在NSTI患者中的临床结果和围手术期资源需求。在2022年9月至2025年1月期间,在一家三级转诊中心进行了一项回顾性病例系列研究,纳入了8例下肢NSTI患者(FTT组,n = 4;LF组,n = 4)。分析了人口统计学数据、合并症、手术时机、并发症情况和资源利用指标,包括手术时间、住院时间和手术次数。所有FTT病例均按照机构方案进行了术前CT血管造影。FTT组明确重建的平均时间更长(17.25天对8天,P = 0.15),这反映了分阶段的感染控制。FTT手术的手术时间明显更长(331.75分钟对170.25分钟,P = 0.015),但总住院时间没有显著差异(34.75天对27.71天,P = 0.65)。未观察到皮瓣丢失或静脉淤血的病例,并且通过延迟悬吊方案优化了结果。结论:FTT是下肢NSTIs一种可行且有效的重建方式。尽管手术复杂性增加,但FTT并未显著增加医院资源利用,支持其在适当选择的患者中保肢的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a03/12072915/612c5f8f3437/jcm-14-02997-g001.jpg

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