• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

下肢坏死性软组织感染的管理:显微外科重建与医院资源需求——来自三级转诊中心的病例系列

Managing Necrotizing Soft Tissue Infections of the Lower Limb: Microsurgical Reconstruction and Hospital Resource Demands-A Case Series from a Tertiary Referral Center.

作者信息

Karamitros Georgios, Grant Michael P, Henry Sharon, Lamaris Gregory A

机构信息

Division of Plastic and Reconstructive Surgery, R. Adams Cowley Shock Trauma Center, University of Maryland Medical Center, Baltimore, MD 21201, USA.

Department of Surgery, R. Adams Cowley Shock Trauma Center, University of Maryland Medical Center, Baltimore, MD 21201, USA.

出版信息

J Clin Med. 2025 Apr 26;14(9):2997. doi: 10.3390/jcm14092997.

DOI:10.3390/jcm14092997
PMID:40364028
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12072915/
Abstract

Necrotizing soft tissue infections (NSTIs) of the lower extremities represent a surgical emergency with high morbidity, complex reconstruction, and considerable healthcare demands. Free tissue transfer (FTT) is increasingly utilized for limb salvage in extensive soft tissue defects, yet its implications for hospital resource utilization remain unclear. This study aims to compare clinical outcomes and perioperative resource demands between FTT and local flap (LF) reconstruction in NSTI patients. A retrospective case series was conducted at a tertiary referral center between September 2022 and January 2025, including eight patients with NSTI of the lower extremity (FTT, = 4; LF, = 4). Demographic data, comorbidities, surgical timing, complication profiles, and resource utilization metrics-including operative duration, hospitalization length, and number of procedures-were analyzed. All FTT cases underwent preoperative CT angiography as part of institutional protocol. Mean time to definitive reconstruction was longer in the FTT group (17.25 vs. 8 days, = 0.15), reflecting staged infection control. FTT procedures demonstrated significantly longer operative times (331.75 vs. 170.25 minutes, = 0.015), but there was no significant difference in total hospital stay (34.75 vs. 27.71 days, = 0.65). No cases of flap loss or venous congestion were observed, and outcomes were optimized via delayed dangling protocols. : FTT is a viable and effective reconstructive modality for lower extremity NSTIs. Despite increased surgical complexity, FTT did not significantly increase hospital resource utilization, supporting its role in limb preservation among appropriately selected patients.

摘要

下肢坏死性软组织感染(NSTIs)是一种外科急症,具有高发病率、复杂的重建需求和巨大的医疗需求。在广泛的软组织缺损中,游离组织移植(FTT)越来越多地用于肢体挽救,但其对医院资源利用的影响仍不清楚。本研究旨在比较FTT和局部皮瓣(LF)重建在NSTI患者中的临床结果和围手术期资源需求。在2022年9月至2025年1月期间,在一家三级转诊中心进行了一项回顾性病例系列研究,纳入了8例下肢NSTI患者(FTT组,n = 4;LF组,n = 4)。分析了人口统计学数据、合并症、手术时机、并发症情况和资源利用指标,包括手术时间、住院时间和手术次数。所有FTT病例均按照机构方案进行了术前CT血管造影。FTT组明确重建的平均时间更长(17.25天对8天,P = 0.15),这反映了分阶段的感染控制。FTT手术的手术时间明显更长(331.75分钟对170.25分钟,P = 0.015),但总住院时间没有显著差异(34.75天对27.71天,P = 0.65)。未观察到皮瓣丢失或静脉淤血的病例,并且通过延迟悬吊方案优化了结果。结论:FTT是下肢NSTIs一种可行且有效的重建方式。尽管手术复杂性增加,但FTT并未显著增加医院资源利用,支持其在适当选择的患者中保肢的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a03/12072915/41dbfff849ea/jcm-14-02997-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a03/12072915/612c5f8f3437/jcm-14-02997-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a03/12072915/41dbfff849ea/jcm-14-02997-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a03/12072915/612c5f8f3437/jcm-14-02997-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a03/12072915/41dbfff849ea/jcm-14-02997-g002.jpg

相似文献

1
Managing Necrotizing Soft Tissue Infections of the Lower Limb: Microsurgical Reconstruction and Hospital Resource Demands-A Case Series from a Tertiary Referral Center.下肢坏死性软组织感染的管理:显微外科重建与医院资源需求——来自三级转诊中心的病例系列
J Clin Med. 2025 Apr 26;14(9):2997. doi: 10.3390/jcm14092997.
2
Free tissue transfer for necrotizing fasciitis reconstruction: A case series.游离组织移植用于坏死性筋膜炎重建:病例系列
Burns. 2017 Nov;43(7):1561-1566. doi: 10.1016/j.burns.2017.04.007. Epub 2017 May 20.
3
Institutional Experience and Orthoplastic Collaboration Associated with Improved Flap-based Limb Salvage Outcomes.机构经验和整形协作与改善基于皮瓣的肢体保肢结果相关。
Clin Orthop Relat Res. 2021 Nov 1;479(11):2388-2396. doi: 10.1097/CORR.0000000000001925.
4
Limb Salvage and Functional Outcomes following Free Tissue Transfer for the Treatment of Recalcitrant Diabetic Foot Ulcers.游离组织移植治疗顽固性糖尿病足溃疡后的肢体挽救及功能结果
J Reconstr Microsurg. 2019 Feb;35(2):117-123. doi: 10.1055/s-0038-1667363. Epub 2018 Aug 12.
5
One-stage reconstruction of composite bone and soft-tissue defects in traumatic lower extremities.创伤性下肢复合骨与软组织缺损的一期重建。
Plast Reconstr Surg. 2004 Nov;114(6):1457-66. doi: 10.1097/01.prs.0000138811.88807.65.
6
Reconstruction of Large Soft Tissue Defects in the Distal Lower Extremity: Free Chain-Linked Bilateral Anterolateral Thigh Perforator Flaps versus Extended Latissimus Dorsi Musculocutaneous Flaps.下肢远端大软组织缺损的修复:游离串联双侧股前外侧穿支皮瓣与背阔肌肌皮瓣延长术的比较
J Pers Med. 2022 Aug 29;12(9):1400. doi: 10.3390/jpm12091400.
7
Free flap reconstruction of elbow soft tissue defects: Lessons learned from 15 years of experience.游离皮瓣重建肘部软组织缺损:15 年经验总结。
Microsurgery. 2024 May;44(4):e31163. doi: 10.1002/micr.31163.
8
Long-Term Outcomes in Patients With Peripheral Arterial Disease Who Undergo Free Flap Reconstruction for Chronic Lower Extremity Wounds.慢性下肢创伤行游离皮瓣重建术的外周动脉疾病患者的长期预后。
Ann Plast Surg. 2023 Jan 1;90(1):61-66. doi: 10.1097/SAP.0000000000003395.
9
Implications of Single-Vessel Runoff on Long-Term Outcomes of Free Tissue Transfer for Lower Extremity Reconstruction.单流出血管对下肢重建游离组织移植长期结果的影响。
J Reconstr Microsurg. 2024 Jun;40(5):384-391. doi: 10.1055/a-2181-7149. Epub 2023 Sep 26.
10
Immediate versus delayed free-tissue transfer salvage of the lower extremity in soft tissue sarcoma patients.
Ann Surg Oncol. 1994 Jan;1(1):11-7. doi: 10.1007/BF02303536.

本文引用的文献

1
Does Dangling the Lower Extremity after Free Flap Reconstruction Reduce Partial Flap Loss? A Multicenter Randomized Controlled Trial.
Plast Reconstr Surg. 2025 Jul 1;156(1):162-169. doi: 10.1097/PRS.0000000000011906. Epub 2024 Dec 3.
2
Enhancing the QUINTET study: Exploring quality of life after open lower limb trauma while strengthening research methodology.加强QUINTET研究:探索下肢开放性创伤后的生活质量,同时强化研究方法。
J Plast Reconstr Aesthet Surg. 2025 Jan;100:34-35. doi: 10.1016/j.bjps.2024.11.013. Epub 2024 Nov 16.
3
Postoperative Day 1 Dangling Protocol with Tissue Oximetry Guidance Decreases Hospital Stay in Lower Extremity Fasciocutaneous Free Flaps: Early Experience.术后第1天,采用组织血氧饱和度监测指导的垂吊方案可缩短下肢游离筋膜皮瓣患者的住院时间:早期经验
Plast Reconstr Surg Glob Open. 2024 Aug 27;12(8):e6097. doi: 10.1097/GOX.0000000000006097. eCollection 2024 Aug.
4
Rate of Free Flap Failure and Return to the Operating Room in Lower Limb Reconstruction: A Systematic Review.下肢重建中游离皮瓣失败率及重返手术室情况:一项系统评价
J Clin Med. 2024 Jul 23;13(15):4295. doi: 10.3390/jcm13154295.
5
"US air pollution and increased incidence of non-syndromic cleft lip/palate": Association does not imply causality.“美国空气污染与非综合征性唇腭裂发病率增加”:关联并不意味着因果关系。
J Plast Reconstr Aesthet Surg. 2024 Mar;90:23-24. doi: 10.1016/j.bjps.2024.01.028. Epub 2024 Feb 1.
6
Necrotizing Fasciitis in Charcot-Marie-Tooth Treated with Debridement, Free Flap, and Extra-Articular Reconstruction.Charcot-Marie-Tooth 病所致坏死性筋膜炎的清创、游离皮瓣和关节外重建治疗
J Am Podiatr Med Assoc. 2023 Nov-Dec;113(6). doi: 10.7547/20-281.
7
Surface to Perforator Index: Assessing the Importance of the Number of Perforators in Successful Harvesting of the Anterolateral Thigh Flap.皮穿支指数:评估前外侧股部皮瓣成功获取中穿支数量的重要性。
J Reconstr Microsurg. 2024 Jun;40(5):392-397. doi: 10.1055/s-0043-1776734. Epub 2023 Dec 7.
8
Necrotizing fasciitis: an update on epidemiology, diagnostic methods, and treatment.坏死性筋膜炎:流行病学、诊断方法和治疗的最新进展。
Curr Opin Infect Dis. 2024 Apr 1;37(2):105-111. doi: 10.1097/QCO.0000000000000988. Epub 2023 Nov 30.
9
Enhanced recovery for acute open lower limb fracture 'fix and flap'.急性下肢开放性骨折“固定与皮瓣”的加速康复。
Injury. 2024 Feb;55(2):111234. doi: 10.1016/j.injury.2023.111234. Epub 2023 Nov 23.
10
The Limb Salvage Approach for the Surgical Management of Necrotizing Soft Tissue Infection.坏死性软组织感染外科治疗的保肢方法
Plast Reconstr Surg Glob Open. 2023 Aug 15;11(8):e5207. doi: 10.1097/GOX.0000000000005207. eCollection 2023 Aug.