Ayar Yavuz, Ersoy Alparslan, Isiktas Sayilar Emel, Yildiz Abdülmecit, Can Fatma Ezgi, Oruc Aysegul
Department of Nephrology, Bursa Faculty of Medicine, Health Sciences University, 16120 Bursa, Turkey.
Department of Nephrology, Faculty of Medicine, Bursa Uludag University, 16059 Bursa, Turkey.
J Clin Med. 2025 May 7;14(9):3232. doi: 10.3390/jcm14093232.
: The success of solid organ transplantation and the consequent increase in the patients on the waiting list has led to an increased utilization of donor kidneys with a high kidney donor profile index (KDPI)/expanded criteria. In our study, patients who underwent transplantation based on the standard and expanded donor criteria were compared in terms of factors affecting graft survival. Data of patients who underwent transplantation from cadavers with standard and extended criteria (SCD, ECD) between 01 July 2011 and 30 June 2016 were evaluated retrospectively. Donor characteristics, treatment type, response and graft characteristics, 1st-, 3rd-, and 5th-year graft survival, and acute rejection rates were analyzed retrospectively. : In terms of the causes of death, cerebrovascular accidents were more common in the ECD group ( < 0.001). Hypertension and diabetes were more common in both donor groups and were detected more frequently in recipients in the ECD group ( < 0.001). The absence of mycophenolate mofetil (MMF) use and the presence of an acute rejection attack adversely affected graft survival at the end of the 1st, 3rd, and 5th years. : The utilization of expanded criteria donors is widespread. Appropriate monitoring of patients undergoing immunosuppressive therapy, especially using mycophenolate mofetil (MMF) and the presence of acute rejection, affect graft survival.
实体器官移植的成功以及随之而来等待名单上患者数量的增加，导致了高肾脏捐赠者特征指数（KDPI）/扩大标准的供体肾脏利用率上升。在我们的研究中，对根据标准和扩大供体标准接受移植的患者在影响移植物存活的因素方面进行了比较。对2011年7月1日至2016年6月30日期间接受标准和扩大标准（SCD、ECD）尸体供肾移植患者的数据进行了回顾性评估。对供体特征、治疗类型、反应和移植物特征、第1年、第3年和第5年的移植物存活率以及急性排斥率进行了回顾性分析。在死亡原因方面，脑血管意外在ECD组更为常见（<0.001）。高血压和糖尿病在两个供体组中都更为常见，并且在ECD组的受者中检测到的频率更高（<0.001）。未使用霉酚酸酯（MMF）以及存在急性排斥发作对第1年、第3年和第5年末的移植物存活产生不利影响。扩大标准供体的使用很普遍。对接受免疫抑制治疗的患者进行适当监测，尤其是使用霉酚酸酯（MMF）以及是否存在急性排斥反应，会影响移植物存活。
