Çağlıyan Ömer, Yazıcı Hilmi, Yaşar Ahmet Can, Bekki Yaşar Çağlar, Tan Sedat, Oymacı Erkan, Öztürk Ahmet Mücteba, Yıldırım Mehmet
Department of Surgical Gastroenterology, University of Health Sciences Türkiye, Başakşehir Çam and Sakura City Hospital, İstanbul, Türkiye.
Department of General Surgery, Marmara University, Pendik Training and Research Hospital, İstanbul, Türkiye.
Turk J Surg. 2025 May 30;41(2):154-159. doi: 10.47717/turkjsurg.2025.6760. Epub 2025 May 13.
Colorectal cancer (CRC) is a major health problem worldwide. According to estimates for the year 2030, cancer will be the number one cause of death for both genders. CRC is the third most common type of cancer and the second most common cause of cancer-related deaths. Various parameters are needed to provide information about the course and prognosis of the disease.
The study included 103 patients diagnosed with CRC between 2017 and 2023. The patients' HALP scores were retrospectively analyzed together with clinical data. The relationship between survival times, disease stage, and treatment response was examined.
The obtained data showed that low HALP scores were associated with worse overall survival. Although the HALP score cut-off value was found to be different in various studies conducted on benign or malignant diseases, a low HALP score indicates a poor prognosis. In our study, a HALP score below 23 was found to be associated with low overall survival.
This study suggests that a low HALP score is associated with poor prognosis and could serve as a valuable prognostic marker in the clinical management of CRC patients. However, certain limitations must be considered. While albumin is a marker of systemic inflammation and nutritional status, its specificity is limited in acute and chronic inflammatory conditions, which may impact the prognostic value of the HALP score. Further investigation into the biological mechanisms underlying this relationship and the potential of the HALP score in predicting treatment response would enhance its clinical applicability.
结直肠癌（CRC）是全球主要的健康问题。据2030年的估计，癌症将成为男女死亡的首要原因。CRC是第三大常见癌症类型，也是癌症相关死亡的第二大常见原因。需要各种参数来提供有关该疾病病程和预后的信息。
该研究纳入了2017年至2023年间诊断为CRC的103例患者。对患者的HALP评分与临床数据进行回顾性分析。研究了生存时间、疾病分期和治疗反应之间的关系。
获得的数据表明，低HALP评分与较差的总生存期相关。尽管在针对良性或恶性疾病进行的各种研究中发现HALP评分的临界值有所不同，但低HALP评分表明预后不良。在我们的研究中，发现HALP评分低于23与低总生存期相关。
本研究表明，低HALP评分与预后不良相关，可作为CRC患者临床管理中有价值的预后标志物。然而，必须考虑某些局限性。虽然白蛋白是全身炎症和营养状况的标志物，但其在急性和慢性炎症状态下的特异性有限，这可能会影响HALP评分的预后价值。进一步研究这种关系背后的生物学机制以及HALP评分在预测治疗反应方面的潜力将提高其临床适用性。
