Duran Ali, Pulat Huseyin, Cay Ferhat, Topal Ugur
Department of General Surgery, Balikesir University, Balikesir, Turkey.
Department of General Surgery, Mersin City Hospital, Mersin, Turkey.
J Coll Physicians Surg Pak. 2022 Jun;32(6):734-739. doi: 10.29271/jcpsp.2022.06.734.
To determine the diagnostic value of the haemoglobin, albumin, lymphocyte, and platelet (HALP) score in predicting axillary lymph node (ALN) involvement.
Observational study.
Department of General Surgery, Balıkesir University and Mersin City Hospital, Turkey from January 2016-December 2021.
Included in the study were 307 patients who underwent surgical treatment for breast cancer. HALP values were calculated by multiplying the haemoglobin, albumin, and lymphocyte values and dividing the resulting value by the platelet number. The patients were divided in two groups, being those with low HALP (Group 1) and high HALP (Group 2) scores. We examined the potential of the HALP score for the prediction of ALN involvement.
Group 1 had 65 patients and the Group 2 had 242 patients. At the cut-off point, a HALP score of <29.01 predicted the presence of axillary involvement with a sensitivity of 84.33% and a specificity of 26.1%. The sentinel lymph node sampling rate was similar in both groups (12.3% vs. 16.9% p=0.365). The presence of positive lymph nodes in the axilla was higher in group 1 (67.7% vs. 53.3% p=0.038). There was no correlation between HALP score, and the metastatic lymph node and total lymph node count.
The use of HALP score alone for the prediction of axillary lymph node positivity in patients with breast cancer is not advised. In the present study, a low HALP score was associated with aggressive tumour activity, such as advanced tumour and axillary lymph node positivity.
Breast cancer, Axillary lymph node involvement, Immunity, Nutrition.
确定血红蛋白、白蛋白、淋巴细胞和血小板（HALP）评分在预测腋窝淋巴结（ALN）受累方面的诊断价值。
观察性研究。
2016年1月至2021年12月，土耳其巴勒克埃西尔大学普通外科和梅尔辛市医院。
本研究纳入了307例接受乳腺癌手术治疗的患者。HALP值通过将血红蛋白、白蛋白和淋巴细胞值相乘，再将所得值除以血小板数来计算。患者分为两组，即HALP评分低的组（第1组）和HALP评分高的组（第2组）。我们研究了HALP评分预测ALN受累的潜力。
第1组有65例患者，第2组有242例患者。在截断点，HALP评分<29.01预测腋窝受累的敏感性为84.33%，特异性为26.1%。两组前哨淋巴结采样率相似（12.3%对16.9%，p = 0.365）。第1组腋窝阳性淋巴结的存在率更高（67.7%对53.3%，p = 0.038）。HALP评分与转移性淋巴结及总淋巴结计数之间无相关性。
不建议单独使用HALP评分来预测乳腺癌患者腋窝淋巴结阳性。在本研究中，低HALP评分与侵袭性肿瘤活动相关，如晚期肿瘤和腋窝淋巴结阳性。
乳腺癌；腋窝淋巴结受累；免疫；营养
