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An update on diagnosis and treatments of childhood interstitial lung diseases.

作者信息

Marczak Honorata, Krenke Katarzyna, Griese Matthias, Carlens Julia, Seidl Elias, Gilbert Carlee, Emiralioglu Nagehan, Torrent-Vernetta Alba, Willemse Brigitte, Epaud Ralph, Delestrain Celine, Louvrier Camille, Koucký Václav, Nathan Nadia

机构信息

Department of Pediatric Pneumology and Allergy, Medical University of Warsaw, Warsaw, Poland.

Department of Paediatric Pneumology, Dr von Hauner Children's Hospital, German Centre for Lung Research, University of Munich, Munich, Germany.

出版信息

Breathe (Sheff). 2025 May 13;21(2):250004. doi: 10.1183/20734735.0004-2025. eCollection 2025 Apr.


DOI:10.1183/20734735.0004-2025
PMID:40365093
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12070201/
Abstract

Childhood interstitial lung diseases (chILDs) are rare and heterogeneous disorders associated with significant morbidity and mortality. The clinical presentation of chILD typically includes chronic or recurrent respiratory signs and symptoms with diffuse radiographic abnormalities on chest imaging. Diagnosis requires a structured, multi-step approach. Treatment options are limited, with disease-specific therapies available only in selected cases and management relying primarily on supportive care. Awareness of chILDs has been steadily increasing. New diagnoses, advanced diagnostic tests, and novel treatments are emerging each year, highlighting the importance of collaborative, multidisciplinary teams in providing comprehensive care for children and families affected by these complex conditions. On behalf of the European Respiratory Society Clinical Research Collaboration for chILD (ERS CRC chILD-EU), this review provides an updated overview of the diagnostic approach and management strategies for chILDs.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1588/12070201/b15b86d920c2/EDU-0004-2025.02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1588/12070201/c6b979c1ec84/EDU-0004-2025.01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1588/12070201/b15b86d920c2/EDU-0004-2025.02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1588/12070201/c6b979c1ec84/EDU-0004-2025.01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1588/12070201/b15b86d920c2/EDU-0004-2025.02.jpg

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An update on diagnosis and treatments of childhood interstitial lung diseases.

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本文引用的文献

[1]
Efficacy and safety of CFTR modulators in patients with interstitial lung disease caused by ABCA3 transporter deficiency.

ERJ Open Res. 2025-3-3

[2]
Vaccination in adult patients with chronic lung diseases.

Praxis (Bern 1994). 2024-12

[3]
Childhood interstitial lung disease survivors in adulthood: a European collaborative study.

Eur Respir J. 2025-2-13

[4]
Surfactant protein B deficiency: the RespiRare cohort.

Thorax. 2025-1-17

[5]
Epidemiology of Traditional Cigarette and E-Cigarette Use Among Adolescents in Poland: Analysis of Sociodemographic Risk Factors.

Int J Environ Res Public Health. 2024-11-10

[6]
Protocol and research program of the European registry and biobank for interstitial lung diseases (eurILDreg).

BMC Pulm Med. 2024-11-18

[7]
Inhaled treatment for dyspnea in a rare childhood disease.

Pediatr Pulmonol. 2024-12

[8]
Ultrasound Evaluation of Interstitial Lung Disease in Rheumatoid Arthritis and Autoimmune Diseases.

Eur J Rheumatol. 2024-1-19

[9]
Interstitial lung disease in infancy and early childhood: Clinical approach.

Pediatr Pulmonol. 2025-3

[10]
Two cases with undefined childhood interstitial lung disease: Can it be related to telomere variants?

J Paediatr Child Health. 2024-11

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