Taddeo Francesco, Ortona Ornella, Ciccarelli Donato, Tesser Riccardo, Grénman Henrik, Di Serio Martino, Russo Vincenzo, Paduano Luigi
Department of Chemical Sciences, University of Naples Federico II Via Cintia IT-80126 Naples Italy
Laboratory of Industrial Chemistry and Reaction Engineering, Åbo Akademi Henrikinkatu 2 FI-20500 Turku/Åbo Finland.
RSC Adv. 2025 May 13;15(20):15701-15711. doi: 10.1039/d5ra00669d. eCollection 2025 May 12.
Glucose is extensively employed to produce sorbitol through catalytic hydrogenation. In the process development, parameters such as fluid dynamic conditions, temperature, and diffusion coefficients must be evaluated. To optimize the production of sorbitol, it is necessary to know the diffusion coefficients of the reacting system. In this study, they were determined at different solute concentrations and temperatures. Diffusion coefficients can also be estimated using models, such as Wilke-Chang and Hayduk and Minhas correlations. The values between 25 °C and 45 °C are similar to the experimental data, while at 65 °C, both models significantly overestimate the experimental results. As for the ternary systems, at 25 °C, both glucose and sorbitol are essentially transported by their concentration gradient. Finally, simulations of reactors operating in laminar flow conditions were made, estimating the diffusion coefficients using the Wilke-Chang correlation and determining them experimentally, showing that the glucose conversion profile along the axis of the reactor was different.
葡萄糖通过催化氢化被广泛用于生产山梨醇。在工艺开发过程中，必须评估诸如流体动力学条件、温度和扩散系数等参数。为了优化山梨醇的生产，有必要了解反应体系的扩散系数。在本研究中，它们是在不同溶质浓度和温度下测定的。扩散系数也可以使用Wilke-Chang和Hayduk以及Minhas关联式等模型来估算。25℃至45℃之间的值与实验数据相似，而在65℃时，两个模型都显著高估了实验结果。至于三元体系，在25℃时，葡萄糖和山梨醇基本上都是通过它们的浓度梯度进行传输的。最后，对在层流条件下运行的反应器进行了模拟，使用Wilke-Chang关联式估算扩散系数并通过实验确定它们，结果表明沿反应器轴线的葡萄糖转化曲线是不同的。
