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并非所有鼻塞都是过敏性鼻炎:一例鼻窦恶性黑色素瘤病例报告

Not every nasal block is allergic rhinitis: a case report of sinonasal malignant melanoma.

作者信息

Naqi Rula, Haridas Vineeth, Kandiyil Ismail, Al-Shehabi Mohammed, Nasser Mai, Al-Abdullah Amal

机构信息

Otolaryngology Department, Bahrain Defence Force Hospital- Royal Medical Services, Rd No 2802, PO Box 28743, Riffa, Kingdom of Bahrain.

出版信息

J Surg Case Rep. 2025 May 13;2025(5):rjaf295. doi: 10.1093/jscr/rjaf295. eCollection 2025 May.

Abstract

Sinonasal malignant melanoma (SNMM) is an extremely rare and aggressive sinonasal tumor. It has nonspecific risk factors and clinical presentation which require a high index of suspicion. In this case report we present a case of a 47-year-old male who initially had persistent nasal obstruction not responding to intranasal steroids. Comprehensive imaging and histopathological studies confirmed SNMM. He underwent incomplete maxillectomy resection followed by immunotherapy abroad. Within 6 months period he had recurrence of the disease. As this disease is a rare entity, there are no specific treatment guidelines, however, surgical intervention is agreed to be the mainstay of treatment. Although their effectiveness is still controversial, radiation therapy, chemotherapy, immunological and biological therapies are adjuvant options. Multidisciplinary team approach is necessary to provide the optimal treatment plan, along with close follow up. Continuous research and clinical trials are still needed to ensure appropriate diagnosis and management of this rare entity.

摘要

鼻窦恶性黑色素瘤(SNMM)是一种极其罕见且侵袭性强的鼻窦肿瘤。它具有非特异性的危险因素和临床表现,需要高度怀疑。在本病例报告中,我们呈现了一名47岁男性的病例,他最初持续鼻塞,对鼻内类固醇治疗无反应。综合影像学和组织病理学研究确诊为SNMM。他在国外接受了上颌骨部分切除术,随后进行了免疫治疗。在6个月内,疾病复发。由于这种疾病是一种罕见病,没有特定的治疗指南,然而,手术干预被认为是主要的治疗方法。尽管其有效性仍存在争议,但放射治疗、化疗、免疫和生物治疗是辅助选择。多学科团队方法对于提供最佳治疗方案以及密切随访是必要的。仍需要持续的研究和临床试验来确保对这种罕见病进行适当的诊断和管理。

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