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鼻窦恶性黑色素瘤的眼部侵犯:一例报告并文献复习

Ocular invasion in sinonasal malignant melanoma: A case report and review of literature.

作者信息

Khademi Bijan, Soltani Sajjad, Yousefi Alireza, Heidari Pouya, Mardani Zhale, Yousufzai Shayan

机构信息

Head and neck Surgery Department, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Iran.

出版信息

Int J Surg Case Rep. 2025 Feb;127:110904. doi: 10.1016/j.ijscr.2025.110904. Epub 2025 Jan 20.

DOI:10.1016/j.ijscr.2025.110904
PMID:39842280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11788794/
Abstract

BACKGROUND

Sinonasal mucosal melanoma (SNMM) is a rare and aggressive malignancy associated a poor prognosis, prognosis. It is by delayed presentation and nonspecific symptoms. The incidence of SNMM is low, with and there are challenges in achieving local control and managing distant metastases.

CASE PRESENTATION

We report present case of an 86-year-old female patient with a history of systemic hypertension who presented exhibited symptoms, including blurred vision, rhinorrhea, and facial pain, following initial treatment for SNMM. sinonasal mucosal melanoma (SNMM). studies revealed a heterogeneous lesion in the right nasal cavity and ethmoidal air cells, exhibiting characterized by destruction and invasion into the orbit. The patient underwent functional endoscopic sinus surgery (FESS) for resection, with and analysis confirming confirmed the diagnosis of melanoma.

DISCUSSION

This case underscores the aggressive nature of SNMM and emphasizes importance of early diagnosis and intervention. Despite Although treatment with surgery and radiotherapy leading resulted in resolution for two years, the recurrence of symptoms highlights the challenges in associated with long-term control. The Effective of SNMM requires necessitates multidisciplinary approach, approach that includes resection and the of adjuvant therapies.

CONCLUSION

SNMM poses presents treatment challenges due to its aggressive behavior nature complex anatomical location. A comprehensive approach involving that includes radiotherapy, and potential systemic therapies is essential for improving enhancing outcomes. Further research is needed necessary explore investigate treatment strategies for this rare malignancy.

摘要

背景

鼻窦黏膜黑色素瘤(SNMM)是一种罕见且侵袭性强的恶性肿瘤,预后较差。其特点是就诊延迟和症状不具特异性。SNMM的发病率较低,在实现局部控制和处理远处转移方面存在挑战。

病例报告

我们报告了一例86岁女性患者,有系统性高血压病史,在初次治疗SNMM后出现视力模糊、流涕和面部疼痛等症状。检查发现右侧鼻腔和筛窦气房有一个异质性病变,其特征为破坏并侵犯眼眶。患者接受了功能性内镜鼻窦手术(FESS)切除,分析证实为黑色素瘤。

讨论

该病例强调了SNMM的侵袭性本质,并强调了早期诊断和干预的重要性。尽管手术和放疗治疗导致症状缓解了两年,但症状复发凸显了长期控制的挑战。SNMM的有效治疗需要多学科方法,包括切除和辅助治疗。

结论

由于其侵袭性行为和复杂的解剖位置,SNMM带来了治疗挑战。包括放疗和潜在的全身治疗在内的综合方法对于改善预后至关重要。需要进一步研究来探索这种罕见恶性肿瘤的治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/11788794/e3a468c5ce61/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/11788794/0d5c934f4c7a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/11788794/8b9b60821bfb/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/11788794/7abd3f64b806/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/11788794/e3a468c5ce61/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/11788794/0d5c934f4c7a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/11788794/8b9b60821bfb/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/11788794/7abd3f64b806/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/11788794/e3a468c5ce61/gr4.jpg

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Prognostic Value of an Immunohistochemical Signature in Patients With Head and Neck Mucosal Melanoma.头颈部黏膜黑色素瘤患者免疫组织化学特征的预后价值。
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Ann Transl Med. 2019 Jul;7(Suppl 3):S118. doi: 10.21037/atm.2019.05.62.
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