药物靶点的遗传变异：我们是否已准备好迎接精准药物化学时代？
Genetic Variation in Drug Targets: Are We Ready for the Era of Precision Medicinal Chemistry?
作者信息
Veale Clinton G L, Edkins Adrienne L
机构信息
Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
Biomedical Biotechnology Research Unit (BioBRU), Department of Biochemistry, Microbiology and Bioinformatics, Rhodes University, Makhanda 6139, South Africa.
出版信息
ACS Med Chem Lett. 2025 Apr 11;16(5):706-710. doi: 10.1021/acsmedchemlett.5c00153. eCollection 2025 May 8.
Natural genetic variations profoundly impact drug target interactions causing variations in in vitro biological data. The overall occurrence or "rare genetic variation" is common and enriched within population groups. Incorporating population-level genetic information earlier into the drug discovery pipeline would allow medicinal chemists to contribute to the precision medicine movement, designing drugs with more population relevance.
自然遗传变异深刻影响药物靶点相互作用，导致体外生物学数据出现差异。总体发生率或“罕见遗传变异”很常见，且在人群组中更为富集。在药物研发流程中更早纳入人群水平的遗传信息，将使药物化学家能够为精准医学的发展做出贡献，设计出与更多人群相关的药物。
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