测量青年期的早期血管衰老：青年血管联盟的专家共识文件。

Measuring early vascular aging in youth: an expert consensus document from the Youth Vascular Consortium.

作者信息

Hersant Jeanne, Kruger Ruan, Bianchini Elisabetta, Königstein Karsten, Sinha Manish D, Hidvégi Erzsébet V, Kodithuwakku Vimarsha, Mill José Geraldo, Diaz Alejandro, Zócalo Yanina, Bia Daniel, Celermajer David, Hanssen Henner, Johansson Madeleine, Pucci Giacomo, Litwin Mieczysław, Stone Keeron, Pugh Christopher J A, Stoner Lee, Urbina Elaine M, Bruno Rosa Maria, Nilsson Peter M, Climie Rachel E

机构信息

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.

Faculty of Medicine, University of Angers, Angers, France.

出版信息

J Hypertens. 2025 May 6. doi: 10.1097/HJH.0000000000004039.

DOI:10.1097/HJH.0000000000004039

PMID:40366131

Abstract

Since the conceptualization of early vascular aging (EVA) in 2008, significant efforts have been made to develop and improve its assessment. Initially lead by the investigation of arterial stiffness through pulse wave velocity (PWV), several additional vascular aging biomarkers have gained prominence in recent years. Despite expanding literature addressing methodological concerns associated with these biomarkers in youth, a standardized approach for clinical evaluation of EVA remains elusive, leaving pertinent gaps in understanding the optimal methodology. This article, resulting from international consensus efforts from the Youth Vascular Consortium, aims to provide an updated overview of methods available to measure EVA in youth and to discuss challenges in translating these methods into clinical practice.

摘要

自2008年提出早期血管衰老（EVA）的概念以来，人们为其评估方法的开发和改进付出了巨大努力。最初主要通过脉搏波速度（PWV）来研究动脉僵硬度，近年来，其他几种血管衰老生物标志物也备受关注。尽管针对这些生物标志物在年轻人中的方法学问题的文献不断增加，但EVA临床评估的标准化方法仍然难以捉摸，在理解最佳方法方面存在相关差距。本文由青年血管联盟的国际共识努力而成，旨在提供可用于测量年轻人EVA的方法的最新概述，并讨论将这些方法转化为临床实践所面临的挑战。