Sukumar Subash, Harper Robert A, Tsamis Emmanouil, Hood Donald, Henson David B
Manchester University NHS Foundation Trust.
Columbia University, NY.
J Glaucoma. 2025 Sep 1;34(9):710-718. doi: 10.1097/IJG.0000000000002596. Epub 2025 May 14.
The diagnostic performance for detecting early glaucoma of a supra-threshold and a threshold visual field tests are compared. Their performance was found to be equivalent with the supra-threshold test being faster.
To compare the diagnostic accuracy of a supra-threshold and a threshold visual field test in detecting early glaucoma using optical coherence tomography (OCT) as the reference standard.
Data from 54 early/suspect glaucoma patients and 37 controls underwent a Humphrey Visual field Analyzer (HFA) SITA standard 24-2 threshold test, a Henson 9000 Smart Supra test (SS) supra-threshold test and Topcon Triton OCT scan: Smart Track 3D Wide (H) (12 × 9). OCT data were classified by 3 experts as either no glaucoma (n=42), suspect (n=6), or glaucoma (n=43). Overall and Selective global indices and receiver operating characteristics (ROC) curve analysis were used to compare visual field outcomes with OCT classifications.
SS was significantly faster than SITA standard (3.9 vs. 6 min). Sixty-one percent of the glaucoma sample and 81% of controls showed substantial agreement between OCT and visual field testing using the most sensitive criteria (Henson-N-miss SS, stage 2 and 3, >0 misses; HFA VFI <99%). The area under the ROC curve showed good discrimination for all global indices. The 24-2 global indices MD, PSD, and VFI ranged from 86% to 89%, whereas those for the SS test ranged from 84% to 88%. Partial area under the ROC curve (80%-100% specificity) showed a fall for all global indices. HFA MD, PSD and VFI range (61%-73%), SS test range (71%-78%).
The SS supra-threshold test was faster and had equivalent diagnostic accuracy to the SITA standard 24-2 threshold test in early/suspect glaucoma.
比较超阈值视野测试和阈值视野测试在以光学相干断层扫描（OCT）作为参考标准检测早期青光眼时的诊断准确性。
54例早期/疑似青光眼患者和37例对照的数据接受了Humphrey视野分析仪（HFA）SITA标准24-2阈值测试、Henson 9000智能超阈值测试（SS）超阈值测试以及Topcon Triton OCT扫描：智能轨迹3D宽视野（H）（12×9）。3位专家将OCT数据分类为无青光眼（n = 42）、疑似（n = 6）或青光眼（n = 43）。使用总体和选择性全局指标以及受试者操作特征（ROC）曲线分析来比较视野结果与OCT分类。
SS明显比SITA标准快（3.9分钟对6分钟）。使用最敏感标准（Henson-N-漏检SS，2期和3期，漏检次数>0；HFA VFI<99%）时，61%的青光眼样本和81%的对照在OCT和视野测试之间显示出高度一致性。ROC曲线下面积对所有全局指标均显示出良好的区分度。24-2全局指标平均偏差（MD）、模式标准差（PSD）和视野指数（VFI）范围为86%至89%，而SS测试的范围为从84%至88%。ROC曲线下部分面积（特异性80%-100%）对所有全局指标均有所下降。HFA MD、PSD和VFI范围（61%-73%），SS测试范围（71%-78%）。
在早期/疑似青光眼患者中，SS超阈值测试更快且诊断准确性与SITA标准24-2阈值测试相当。
比较了超阈值视野测试和阈值视野测试检测早期青光眼的诊断性能。发现它们的性能相当，且超阈值测试速度更快。
