Vision, Imaging and Performance Laboratory, Duke Eye Center and Department of Ophthalmology, Duke University, Durham, North Carolina.
Campbell University School of Medicine, Lillington, North Carolina.
Ophthalmol Glaucoma. 2023 Mar-Apr;6(2):187-197. doi: 10.1016/j.ogla.2022.08.017. Epub 2022 Sep 7.
To compare the performance of the 10-2 test versus 24-2 standard automated perimetry (SAP) test for the diagnosis of glaucoma using OCT as an independent standard for glaucomatous damage.
Cross-sectional study.
A total of 1375 pairs of 10-2 and 24-2 SAP tests from 569 eyes of 339 subjects were used for the analysis. A total of 440 (77%) eyes had a diagnosis of glaucoma, and 129 (23%) eyes were normal. All participants underwent 10-2 and 24-2 SAP tests within 30 days.
Glaucomatous severity was quantified based on OCT macula ganglion cell layer (mGCL) and circumpapillary retinal nerve fiber layer. The area under the receiver operating characteristic (ROC) curve (AUC) was used to compare 10-2 and 24-2 metrics for discriminating healthy eyes from those of glaucoma, at different levels of disease severity.
Areas under the ROC curves and sensitivities at fixed specificities of 80% and 95%.
The overall AUC for mean deviation (MD) for the 24-2 test (0.808) was significantly higher than that of the 10-2 test (0.742; P < 0.001). When compared at different stages of the disease, the 24-2 test performed generally better than the 10-2 test, notably in the earlier stages of the disease. For early damage (first quartile), the 24-2 MD had an AUC of 0.658 versus 0.590 for 10-2 MD (P = 0.018). For advanced damage (fourth quartile), corresponding values were 0.954 vs. 0.903 (P = 0.013). Similar trends were observed when glaucoma severity was defined based on structural macular damage with mGCL thickness.
The 24-2 SAP test had better diagnostic accuracy compared with that of the 10-2 test for detecting equivalent levels of glaucomatous damage, as measured by quantitative assessment of retinal nerve fiber layer and macula by OCT.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
使用 OCT 作为青光眼损害的独立标准，比较 10-2 测试与 24-2 标准自动视野计 (SAP) 测试在青光眼诊断中的性能。
横断面研究。
共使用了来自 339 名受试者 569 只眼中的 1375 对 10-2 和 24-2 SAP 测试进行分析。共有 440 只（77%）眼被诊断为青光眼，129 只（23%）眼正常。所有参与者在 30 天内接受了 10-2 和 24-2 SAP 测试。
根据 OCT 黄斑神经节细胞层 (mGCL) 和环周视网膜神经纤维层定量评估青光眼严重程度。使用接收器工作特征 (ROC) 曲线下的面积 (AUC) 比较 10-2 和 24-2 指标在不同疾病严重程度下区分健康眼和青光眼眼的能力。
ROC 曲线下面积和固定特异性为 80%和 95%时的灵敏度。
24-2 测试的平均偏差 (MD) 的总体 AUC（0.808）显著高于 10-2 测试的 AUC（0.742；P<0.001）。当在疾病的不同阶段进行比较时，24-2 测试的性能通常优于 10-2 测试，尤其是在疾病的早期阶段。对于早期损伤（第一四分位数），24-2 MD 的 AUC 为 0.658，而 10-2 MD 的 AUC 为 0.590（P=0.018）。对于晚期损伤（第四四分位数），相应的值分别为 0.954 与 0.903（P=0.013）。当根据黄斑结构损伤（通过 mGCL 厚度评估）定义青光眼严重程度时，观察到类似的趋势。
使用 OCT 定量评估视网膜神经纤维层和黄斑，与 10-2 测试相比，24-2 SAP 测试在检测等效水平的青光眼损害方面具有更好的诊断准确性。
参考文献后可能会有专有或商业披露。
