Joshi Abhishek, Lehene Shubham, Mishra Ashish
Department of Pharmacology, Dr. Chunibhai Vallabbhai Patel College of Pharmacy, Uka Tarsadia University, Maliba Campus, Bardoli, Gujarat, India.
Meril Healthcare Pvt. Ltd, Vapi, 396191, Gujarat, India.
Mol Biol Rep. 2025 May 14;52(1):456. doi: 10.1007/s11033-025-10549-5.
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by progressive memory loss and cognitive decline. It involves the irreversible destruction of higher brain structures, leading to significant cognitive deficits, personality changes, and aberrant behavior. Key pathological features include the accumulation of amyloid-beta (Aβ) plaques and hyperphosphorylated tau protein neurofibrillary tangles, which disrupt cellular communication and neuron function. Chronic inflammation, vascular abnormalities, and genetic factors like the APOE (apolipoprotein E) ε4 allele also play crucial roles in AD progression. Epidemiological data indicate a substantial global impact, especially among older adults, with women disproportionately affected. Animal models, both transgenic and non-transgenic, are pivotal in researching AD pathophysiology and potential treatments. This review presents a full overview regarding a variety of non-transgenic rodent models of Alzheimer's disease utilized in the preclinical research for treatment approaches in Alzheimer's disease.
阿尔茨海默病（AD）是一种常见的神经退行性疾病，其特征为进行性记忆丧失和认知衰退。它涉及大脑高级结构的不可逆破坏，导致显著的认知缺陷、人格改变和异常行为。关键的病理特征包括β-淀粉样蛋白（Aβ）斑块的积累和过度磷酸化的tau蛋白神经原纤维缠结，它们会破坏细胞通讯和神经元功能。慢性炎症、血管异常以及载脂蛋白E（APOE）ε4等位基因等遗传因素在AD进展中也起着关键作用。流行病学数据表明，AD对全球影响巨大，尤其是在老年人中，女性受影响的比例更高。转基因和非转基因动物模型在研究AD病理生理学和潜在治疗方法方面至关重要。本综述全面概述了在阿尔茨海默病治疗方法临床前研究中使用的各种非转基因啮齿动物阿尔茨海默病模型。
