Elhady Fatma, Ali Asmaa Ahmed, Elkholy Naglaa Shaban, El-Mnakhly Eman A, Said Abd Elkareem Taher, Galal Ahmed, Negm Mahmoud A
Cardiology Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.
Internal Medicine Department Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.
Int J Cardiovasc Imaging. 2025 May 14. doi: 10.1007/s10554-025-03415-9.
The left atrium (LA) has a vital role in diastolic function. One of the predictors of diastolic dysfunction (DD) is the LA reservoir strain. Beside this, stiffness of LA is considered another marker for LA function. Moreover, it is correlated with the degree of fibrosis than LA deformity itself. Aim of the study is to evaluate the LA phasic function, stiffness in patients with type II diabetes mellitus and whether these parameters could be the earlier markers of DD in T2DM. Also, to assess the effect of duration of T2DM on LA function. 103individuals, comprising 73patients with type II diabetes and 30 age and sex matched healthy control, depending on duration of diabetes, the patient group was classified into three groups, the first group (less than 10 years), group II (10-20 years) &group III (more than 20 years).2D-TTE was done for assessment of LA functions. Increased indexed LA volume (LAVI)&decreased LA phasic function in diabetic group(A). Elevated LA stiffness index earlier in diabetic patients (Group I) (p 0.02). There were significant differences between group I versus group II, III in LA function when measured by STE and between group I versus group II in LA stiffness index. We found that duration of diabetes is correlated negatively with LA function.LA filling index is positively correlated significantly with LA stiffness index p < 0.001, MV E, E/e', LAVI. The duration of diabetes was one of the predictors of LA dysfunction. Elevated LA stiffness with impaired its phasic function in diabetic patients. LA stiffness index and phasic function can be used as an earlier marker for diastolic dysfunction. Duration of diabetes has an effect on LA function and stiffness index.
左心房（LA）在舒张功能中起着至关重要的作用。舒张功能障碍（DD）的预测指标之一是左心房储备应变。除此之外，左心房的僵硬度被认为是左心房功能的另一个标志。此外，与左心房畸形本身相比，它与纤维化程度相关。本研究的目的是评估2型糖尿病患者的左心房阶段性功能、僵硬度，以及这些参数是否可能是2型糖尿病舒张功能障碍的早期标志物。同时，评估2型糖尿病病程对左心房功能的影响。103名个体，包括73名2型糖尿病患者和30名年龄及性别匹配的健康对照者，根据糖尿病病程，患者组被分为三组，第一组（少于10年）、第二组（10 - 20年）和第三组（超过20年）。进行二维经胸超声心动图（2D - TTE）以评估左心房功能。糖尿病组左心房容积指数（LAVI）增加且左心房阶段性功能降低（A）。糖尿病患者（第一组）早期左心房僵硬度指数升高（p < 0.02）。通过应变弹性成像（STE）测量时，第一组与第二组、第三组在左心房功能方面存在显著差异，且第一组与第二组在左心房僵硬度指数方面存在显著差异。我们发现糖尿病病程与左心房功能呈负相关。左心房充盈指数与左心房僵硬度指数、二尖瓣E峰、E/A'、LAVI呈显著正相关（p < 0.001）。糖尿病病程是左心房功能障碍的预测指标之一。糖尿病患者左心房僵硬度升高且其阶段性功能受损。左心房僵硬度指数和阶段性功能可作为舒张功能障碍的早期标志物。糖尿病病程对左心房功能和僵硬度指数有影响。
