Chaurasia Ujjain, Parvin Tasneem
Department of Chemical Science and Technology, National Institute of Technology Patna, Patna, Bihar, 800005, India.
Mol Divers. 2025 May 14. doi: 10.1007/s11030-025-11201-x.
2-Amino-1,4-naphthoquinone has gained significant attention as a key precursor for constructing naphthoquinone-fused N-heterocycles, a class of compounds with broad applications in medicinal chemistry, materials science, and organic synthesis. Its unique structure, characterized by a reactive C-3 position and an amino group, facilitates a wide range of reactions and synthetic strategies. This review provides a comprehensive overview of recent advancements (2012-2024) in utilizing 2-amino-1,4-naphthoquinone for the development of N-heterocyclic frameworks integrating synthetic approaches with mechanistic insights. It is organized based on the type of heterocyclic rings formed, leveraging the C,N-binucleophilic properties of 2-amino-1,4-naphthoquinone.
2-氨基-1,4-萘醌作为构建萘醌稠合N-杂环的关键前体受到了广泛关注，这类化合物在药物化学、材料科学和有机合成中有着广泛的应用。其独特的结构，以活性C-3位和氨基为特征，促进了广泛的反应和合成策略。本综述全面概述了2012年至2024年期间利用2-氨基-1,4-萘醌开发N-杂环骨架的最新进展，将合成方法与机理见解相结合。它是根据形成的杂环类型进行组织的，利用了2-氨基-1,4-萘醌的C，N-双亲核性质。
