Fatani Mohammad Ibrahim, Binamer Yousef, Almudaiheem Hajer Y, Eshmawi Maysa Tariq, Aljehani Fawaz Hamdi, Alshammari Sultanah, Al-Jedai Ahmed H
Hera General Hospital, Makkah, Saudi Arabia.
Department of Dermatology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.
Dermatol Ther (Heidelb). 2025 May 14. doi: 10.1007/s13555-025-01436-9.
Psoriasis is a chronic immune-mediated inflammatory disease characterized by significant variability in clinical presentation and associated comorbidities. We aimed to describe the baseline demographic and clinical characteristics of patients with psoriasis enrolled in the Psoriasis Registry in Saudi Arabia (PSORSA).
This multicenter cohort study included patients with moderate-to-severe psoriasis from 40 hospitals in Saudi Arabia. Baseline demographics, clinical, and comorbidity data were collected and analyzed. Follow-up assessments were conducted every three months for one year.
In total, 482 patients were enrolled. The mean age at diagnosis was 32.2 years, with a median disease duration of 848 days and a mean body mass index of 27.32 kg/m. Male patients comprised 51.8% of the cohort, and 96.5% were Saudi nationals. A positive family history of psoriasis was reported in 17.2% of the participants. A total of 83 patients (17.2%) were documented to have comorbidities. Among these 83 patients, 47 (56.6%) had psoriatic arthritis, 20 (24.1%) had diabetes, and 14 (16.9%) had hypertension. Plaque psoriasis was the most common subtype (94.2%), and the most affected body regions were the upper and lower extremities (88.1% and 85.5%, respectively), followed by the scalp and trunk (75.7% each). The mean PASI score at baseline was 25 ± 13.3, which decreased to 0.32 ± 0.94 by week > 52. Conventional systemic therapies were prescribed to 22.6% of the patients, with methotrexate being the most common agent (18%). Biologic therapies were prescribed to 28.9% of the patients, with adalimumab being the most commonly used (21%). In addition, 12.7% of the cohort received phototherapy. Adverse events occurred in 2.1% of the patients, with cyclosporine contributing to 25% of the reported events.
The PSORSA registry provides valuable insights into the demographics, clinical characteristics, and treatment patterns of patients with psoriasis in Saudi Arabia. These findings emphasize the need for real-world data to guide regional psoriasis management strategies.
银屑病是一种慢性免疫介导的炎症性疾病，其临床表现和相关合并症具有显著变异性。我们旨在描述纳入沙特阿拉伯银屑病登记处（PSORSA）的银屑病患者的基线人口统计学和临床特征。
这项多中心队列研究纳入了沙特阿拉伯40家医院的中重度银屑病患者。收集并分析了基线人口统计学、临床和合并症数据。随访评估每三个月进行一次，为期一年。
总共纳入了482例患者。诊断时的平均年龄为32.2岁，疾病中位数持续时间为848天，平均体重指数为27.32kg/m。男性患者占队列的51.8%，96.5%为沙特国民。17.2%的参与者报告有银屑病家族史。共有83例患者（17.2%）被记录有合并症。在这83例患者中，47例（56.6%）患有银屑病关节炎，20例（24.1%）患有糖尿病，14例（16.9%）患有高血压。斑块状银屑病是最常见的亚型（94.2%），最常受累的身体部位是上肢和下肢（分别为88.1%和85.5%），其次是头皮和躯干（各为75.7%）。基线时的平均PASI评分为25±13.3，在>52周时降至0.32±0.94。22.6%的患者接受了传统全身治疗，其中甲氨蝶呤是最常用的药物（18%）。28.9%的患者接受了生物治疗，其中阿达木单抗是最常用的（21%）。此外，12.7%的队列接受了光疗。2.1%的患者发生了不良事件，环孢素导致了25%的报告事件。
PSORSA登记处为沙特阿拉伯银屑病患者的人口统计学、临床特征和治疗模式提供了有价值的见解。这些发现强调了需要真实世界数据来指导区域银屑病管理策略。
