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基孔肯雅病毒的持续性宫颈感染

Persistent Cervical Infection with the Chikungunya Virus.

作者信息

Pérez-Pérez José Eduardo, Guzmán-Martínez Oscar, Torres-Flores Jesús Miguel, Sampieri Clara Luz, Pérez-Carreón Julio Isael, López-Balderas Nayali, Barragán Miguel Ángel, Mendoza-Cervantes Guillermo, García-García Fabio, Campos Alma, Sánchez-Marín David, Montero Hilda

机构信息

Instituto de Salud Pública, Universidad Veracruzana, Xalapa, Veracruz, México.

Instituto de Ciencias de la Salud, Universidad Veracruzana, Xalapa, Veracruz, México.

出版信息

Rev Soc Bras Med Trop. 2025 May 9;58:e008122025. doi: 10.1590/0037-8682-0304-2024. eCollection 2025.

DOI:10.1590/0037-8682-0304-2024
PMID:40366994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12064183/
Abstract

Chikungunya virus (CHIKV) induces an acute infection known as chikungunya fever; however, the persistence of CHIKV infections has been reported. This report investigated the persistence of CHIKV over six months in the cervix of two infected women. The infectious CHIKV was isolated from three samples. Our findings demonstrated the persistence of CHIKV in the cervix, highlighting the importance of evaluating other tissue types.

摘要

基孔肯雅病毒（CHIKV）可引发一种名为基孔肯雅热的急性感染；然而，已有报道称CHIKV感染会持续存在。本报告调查了两名受感染女性宫颈中CHIKV持续六个月以上的情况。从三个样本中分离出了具有传染性的CHIKV。我们的研究结果证明了CHIKV在宫颈中的持续存在，突出了评估其他组织类型的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/12064183/597111049970/1678-9849-rsbmt-58-e00812-2025-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/12064183/597111049970/1678-9849-rsbmt-58-e00812-2025-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/12064183/597111049970/1678-9849-rsbmt-58-e00812-2025-gf1.jpg

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本文引用的文献

1
Chikungunya Virus Shedding in Semen: A Case Series.基孔肯雅病毒在精液中的排出：病例系列。
Viruses. 2022 Aug 26;14(9):1879. doi: 10.3390/v14091879.
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A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development.基孔肯雅热病毒的流行病学、发病机制和当前疫苗开发研究进展综述。
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Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein.关节炎病毒受体 MXRA8 与基孔肯雅病毒包膜蛋白结合的分子基础。
Cell. 2019 Jun 13;177(7):1714-1724.e12. doi: 10.1016/j.cell.2019.04.008. Epub 2019 May 9.
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Tropism of the Chikungunya Virus.基孔肯雅热病毒的趋向性。
Viruses. 2019 Feb 20;11(2):175. doi: 10.3390/v11020175.
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Case Reports: Prolonged Detection of Zika Virus RNA in Vaginal and Endocervical Samples from a Brazilian Woman, 2018.病例报告：2018 年巴西女性阴道和宫颈拭子中寨卡病毒 RNA 的长时间检测
Am J Trop Med Hyg. 2019 Jan;100(1):183-186. doi: 10.4269/ajtmh.18-0623.
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Probable female to male sexual transmission of dengue virus infection.登革病毒感染可能存在从女性到男性的性传播。
Infect Dis (Lond). 2019 Feb;51(2):150-152. doi: 10.1080/23744235.2018.1521004. Epub 2018 Oct 14.
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Symptomatic Zika Virus Infection in Infants, Children, and Adolescents Living in Puerto Rico.波多黎各居住的婴儿、儿童和青少年的有症状寨卡病毒感染。
JAMA Pediatr. 2018 Jul 1;172(7):686-693. doi: 10.1001/jamapediatrics.2018.0870.
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Virus in Semen and the Risk of Sexual Transmission.精液中的病毒与性传播风险
N Engl J Med. 2018 Apr 12;378(15):1440-1441. doi: 10.1056/NEJMe1803212.
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Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies.基孔肯雅病毒：流行病学、复制、致病机制及前瞻性干预策略
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