Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Paraná, Brazil.
Department of Nursing, Universidade Estadual de Maringá, Paraná, Brazil.
Am J Trop Med Hyg. 2019 Jan;100(1):183-186. doi: 10.4269/ajtmh.18-0623.
Zika virus (ZIKV) infection is an emerging public health problem, associated with increased risk for Guillain-Barré syndrome and adverse fetal outcomes, including congenital microcephaly. Zika virus sexual transmission is known, but detection of the virus in different parts of the female reproductive tract is not well established. In this case report, we describe prolonged detection of ZIKV RNA in the vaginal secretion and endocervical mucosa from a Brazilian woman convalescent to ZIKV infection. A viral load of 2 × 10 copies/mL was detected up to 31 days after symptom onset in both samples. Other biological fluids, including whole blood, plasma, serum, urine, and saliva samples, were negative for ZIKV RNA. These findings advance the understanding of ZIKV infection and provide data for additional testing strategies.
寨卡病毒（ZIKV）感染是一个新出现的公共卫生问题，与吉兰-巴雷综合征风险增加以及包括先天性小头畸形在内的不良胎儿结局相关。已知寨卡病毒可通过性传播，但在女性生殖道的不同部位检测到该病毒的情况尚未得到很好的确立。在本病例报告中，我们描述了一位巴西女性在寨卡病毒感染后康复过程中，阴道分泌物和宫颈黏膜中寨卡病毒 RNA 的长时间检测。在两个样本中，均在症状出现后 31 天检测到 2×10 拷贝/mL 的病毒载量。其他生物体液，包括全血、血浆、血清、尿液和唾液样本，寨卡病毒 RNA 检测均为阴性。这些发现有助于加深对寨卡病毒感染的认识，并为进一步的检测策略提供数据。
