Lindholm T S, Nilsson O S, Lindholm T C
Acta Vitaminol Enzymol. 1985;7(1-2):39-47.
By feeding adult male rats a calcium deficient diet for a period of 6 weeks osteoporosis can be induced with respect to significant changes in mass, turnover, chemical composition, and morphology of bone and parathyroid glands. When subsequently treating the osteoporotic rats with a combination of 1-alpha-OH-cholecalciferol (1-alpha-OH-D3) and optimal calcium intake osteoporosis as well as morphologic changes of parathyroids can be almost totally reversed as soon as after 2 weeks and completely after 4 and 6 weeks. Notwithstanding the change to an optimal calcium intake seems to be more important in normalizing the osteoporotic skeleton resulting from calcium deficiency than is the ingestion of 1-alpha-OH-D3, which may per se induce new bone formation.
通过给成年雄性大鼠喂食6周缺钙饮食，可诱导其骨骼和甲状旁腺在质量、周转率、化学成分及形态方面发生显著变化，从而引发骨质疏松。随后，用1-α-羟基胆钙化醇（1-α-OH-D3）与最佳钙摄入量联合治疗骨质疏松大鼠，2周后骨质疏松及甲状旁腺的形态变化几乎可完全逆转，4周和6周后则可完全逆转。尽管如此，对于因缺钙导致的骨质疏松骨骼，恢复到最佳钙摄入量似乎比摄入1-α-OH-D3在使其恢复正常方面更为重要，因为1-α-OH-D3本身可能会诱导新骨形成。
