Lindholm T S, Nilsson O S, Lindholm T C
Clin Orthop Relat Res. 1982 Jan-Feb(162):264-9.
Adult male rats reared on a standard diet were treated with peroral dosages of 1 alpha-hydroxyvitamin D3 (1 alpha-OHD3). A rapid effect on the serum calcium level was found; the elevation (compared to untreated controls) occurred as early as two weeks and remained elevated throughout the treatment period. Histomorphometric analysis revealed a decreased resorption rate and increased incorporation of tetracycline after four weeks of 1 alpha-OHD3 treatment. These results were associated with a significant increase of cortical as well as trabecular bone, as well as increased levels of bone hydroxyproline and hexosamines. A clearly significant decrease in the total volume of parathyroids was found after six weeks; this was accompanied by a slight pycnosis of the chief cells, which may account for reduced parathyroid activity.
用标准饮食饲养的成年雄性大鼠经口给予1α-羟基维生素D3（1α-OHD3）。发现其对血清钙水平有快速影响；与未治疗的对照组相比，早在两周时血清钙水平就开始升高，并在整个治疗期间一直保持升高。组织形态计量学分析显示，1α-OHD3治疗四周后，骨吸收速率降低，四环素掺入增加。这些结果与皮质骨和小梁骨显著增加以及骨羟脯氨酸和己糖胺水平升高有关。六周后发现甲状旁腺总体积明显减少；同时主细胞有轻微固缩，这可能是甲状旁腺活性降低的原因。
