Propoxyphene dependence and withdrawal.

Despite the widespread use of propoxyphene products as analgesics, there is no profile of a typical abuser of propoxyphene. Propoxyphene is structurally related to methadone and has central nervous system effects similar to those of opioids. The patient with dependence needs professional help in withdrawing from propoxyphene, in finding an alternative regimen for management of pain and in connecting with self-help programs focusing on life without chemical dependence.