Raghunathan Kavya, Eroglu Cagla
The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.
The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA; The Department of Neurobiology, Duke University Medical Center, Durham, NC, USA; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA.
Curr Opin Neurobiol. 2025 Jun;92:103042. doi: 10.1016/j.conb.2025.103042. Epub 2025 May 13.
Astrocytes, the perisynaptic glial cells of the brain, play fundamental roles in sculpting synaptic circuits and instructing their remodeling and maturation during development. Astrocytes do so through a plethora of cell adhesion and secretory signaling to neurons. This rich communication between astrocytes and neurons is critical for balancing inhibitory and excitatory synaptic connectivity. Additionally, astrocytes refine neural circuits via synaptic engulfment and elimination. Here, we will review recent findings highlighting the diversity and significance of astrocyte-to-neuron communication during developmental circuit wiring. Moreover, we will point out emerging mechanisms of how neurons instruct astrocytes' maturation and synaptic functions to spotlight the essential bidirectional communication between these two cell types in shaping synaptic circuits during neurodevelopment.
星形胶质细胞是大脑中突触周围的神经胶质细胞，在发育过程中塑造突触回路并指导其重塑和成熟方面发挥着重要作用。星形胶质细胞通过与神经元之间大量的细胞粘附和分泌信号传导来实现这一点。星形胶质细胞与神经元之间这种丰富的通讯对于平衡抑制性和兴奋性突触连接至关重要。此外，星形胶质细胞通过突触吞噬和清除来优化神经回路。在这里，我们将回顾最近的研究发现，这些发现突出了发育性回路布线过程中星形胶质细胞与神经元通讯的多样性和重要性。此外，我们将指出神经元指导星形胶质细胞成熟和突触功能的新机制，以强调这两种细胞类型之间在神经发育过程中塑造突触回路时必不可少的双向通讯。
