Séjourné Gabrielle, Eroglu Cagla
The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.
The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA; The Department of Neurobiology, Duke University Medical Center, Durham, NC, USA; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA.
Curr Opin Neurobiol. 2024 Dec;89:102925. doi: 10.1016/j.conb.2024.102925. Epub 2024 Oct 1.
A fundamental feature shared across neurodevelopmental disorders (NDDs) is the disruption of synaptic circuit formation and homeostasis. During early life, non-neuronal cells called astrocytes tightly regulate the establishment of circuits by controlling formation, remodeling, stabilization, and maturation of synapses. Concurrently, astrocytes mature to meet the evolving needs of the developing brain. Bidirectional astrocyte-neuron communication synchronizes astrocyte maturation with synapse development. An emerging body of evidence supports the hypothesis that in NDDs, deficits in astrocyte-neuron communication underlie errors in synaptic circuit development. Here we will review and discuss these findings, with the aim of inspiring future research and guiding translational studies.
神经发育障碍（NDDs）共有的一个基本特征是突触回路形成和稳态的破坏。在生命早期，称为星形胶质细胞的非神经元细胞通过控制突触的形成、重塑、稳定和成熟来严格调节回路的建立。同时，星形胶质细胞成熟以满足发育中大脑不断变化的需求。星形胶质细胞与神经元之间的双向通讯使星形胶质细胞成熟与突触发育同步。越来越多的证据支持这样一种假说，即在神经发育障碍中，星形胶质细胞与神经元通讯的缺陷是突触回路发育错误的基础。在此，我们将回顾和讨论这些发现，以期激发未来的研究并指导转化研究。
